Detailed information of TA system TA204566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2546041..2546564
• Replicon: chromosome
• Accession: NZ_CP076028
• Organism: Staphylococcus sp. MZ8

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KI239_RS12605
• Protein ID: WP_045177693.1
• Coordinates: 2546041..2546307 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KI239_RS12610
• Protein ID: WP_000587618.1
• Coordinates: 2546307..2546564 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI239_RS12585 (KI239_12585)	2541347..2542534	-	1188	WP_045177690.1	MFS transporter	-
KI239_RS12590 (KI239_12590)	2542930..2543706	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
KI239_RS12595 (KI239_12595)	2543699..2544361	-	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
KI239_RS12600 (KI239_12600)	2544609..2545685	-	1077	WP_001076673.1	M42 family metallopeptidase	-
KI239_RS12605 (KI239_12605)	2546041..2546307	-	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
KI239_RS12610 (KI239_12610)	2546307..2546564	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI239_RS12615 (KI239_12615)	2546924..2547379	+	456	WP_000732090.1	YehR family lipoprotein	-
KI239_RS12620 (KI239_12620)	2547547..2549124	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KI239_RS12625 (KI239_12625)	2549319..2550068	+	750	WP_000072443.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T204566 WP_045177693.1 NZ_CP076028:c2546307-2546041 [Staphylococcus sp. MZ8]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T204566 NZ_CP100765:c3872764-3872375 [Serratia nematodiphila]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTTATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCGTTACGGTGTGGCTAAACGGCGGAGCAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGCAAAATCCTGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT204566 WP_000587618.1 NZ_CP076028:c2546564-2546307 [Staphylococcus sp. MZ8]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT204566 NZ_CP100765:c3873031-3872768 [Serratia nematodiphila]
ATGGAAAGGATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAACATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCCTTCTCAGAGGAAGAGTAG

Structures

Antitoxin

• AlphaFold DB: T1YBB2