Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2489504..2490021 | Replicon | chromosome |
| Accession | NZ_CP076028 | ||
| Organism | Staphylococcus sp. MZ8 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KI239_RS12330 | Protein ID | WP_000113262.1 |
| Coordinates | 2489504..2489770 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KI239_RS12335 | Protein ID | WP_000584499.1 |
| Coordinates | 2489770..2490021 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI239_RS12305 (KI239_12305) | 2484931..2485467 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KI239_RS12310 (KI239_12310) | 2485700..2486524 | - | 825 | WP_045177662.1 | formate/nitrite transporter family protein | - |
| KI239_RS12315 (KI239_12315) | 2486741..2486923 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| KI239_RS12320 (KI239_12320) | 2487007..2487474 | - | 468 | WP_000153346.1 | SRPBCC domain-containing protein | - |
| KI239_RS12325 (KI239_12325) | 2487660..2489210 | - | 1551 | WP_045177665.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KI239_RS14275 | 2489398..2489469 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| KI239_RS12330 (KI239_12330) | 2489504..2489770 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KI239_RS12335 (KI239_12335) | 2489770..2490021 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KI239_RS12340 (KI239_12340) | 2490186..2490287 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| KI239_RS12345 (KI239_12345) | 2490294..2490893 | - | 600 | WP_000162812.1 | DsbA family protein | - |
| KI239_RS12350 (KI239_12350) | 2490912..2491274 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KI239_RS12355 (KI239_12355) | 2491529..2492779 | + | 1251 | WP_001012241.1 | FemA/FemB family glycyltransferase FmhA | - |
| KI239_RS12360 (KI239_12360) | 2492876..2493607 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KI239_RS12365 (KI239_12365) | 2493604..2494323 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T204563 WP_000113262.1 NZ_CP076028:c2489770-2489504 [Staphylococcus sp. MZ8]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T204563 NZ_CP100765:3089310-3089513 [Serratia nematodiphila]
GTGAAGAGTTCAGAACTGATTGCGCTGCTGGAAAGCCACGGTTGGGTATTGCGGCGGGTAAAAGGCAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTGCCGCATCCAAAGAAAGATCTCAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTAAGTGCGCTTCACATCGCCACGCGTTAA
GTGAAGAGTTCAGAACTGATTGCGCTGCTGGAAAGCCACGGTTGGGTATTGCGGCGGGTAAAAGGCAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTGCCGCATCCAAAGAAAGATCTCAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTAAGTGCGCTTCACATCGCCACGCGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT204563 WP_000584499.1 NZ_CP076028:c2490021-2489770 [Staphylococcus sp. MZ8]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT204563 NZ_CP100765:3089525-3089938 [Serratia nematodiphila]
ATGTTTTATCCCGCTTATATCCATACAGAATCAAACGGCAGCGCCAGCGGTTTCTTTCCCGACGTCCCTGGCTGCTACTT
CGCCGGCACCAGCCTGGACGACGCTTTTGCCGATGCCCAAAGCGCACTGGATGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAACCGCTACCGCGCCCGCATGCCGTCGCAGCCCATCTTGCCAAAGATGCGGGATCCTTCGAGGGAGGACAATGGCTA
TTGGTCGCTATCAATATGGATAAATTTGACGGCCGAGCCGAACGGATTAACATCACGTTGCCCCATCGCCTGTTAAGTCG
CATTGACTCTCTGGTTCGGCAACATCCGGGATACGGCAGCCGCAGCGGATTTCTCGCCGCCGCCGCGCGCAATGAATTGT
TGAAAGCAGAGTGA
ATGTTTTATCCCGCTTATATCCATACAGAATCAAACGGCAGCGCCAGCGGTTTCTTTCCCGACGTCCCTGGCTGCTACTT
CGCCGGCACCAGCCTGGACGACGCTTTTGCCGATGCCCAAAGCGCACTGGATGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAACCGCTACCGCGCCCGCATGCCGTCGCAGCCCATCTTGCCAAAGATGCGGGATCCTTCGAGGGAGGACAATGGCTA
TTGGTCGCTATCAATATGGATAAATTTGACGGCCGAGCCGAACGGATTAACATCACGTTGCCCCATCGCCTGTTAAGTCG
CATTGACTCTCTGGTTCGGCAACATCCGGGATACGGCAGCCGCAGCGGATTTCTCGCCGCCGCCGCGCGCAATGAATTGT
TGAAAGCAGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|