Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 915732..916146 Replicon chromosome
Accession NZ_CP076028
Organism Staphylococcus sp. MZ8

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI239_RS04460 Protein ID WP_025174939.1
Coordinates 915732..915983 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI239_RS04465 Protein ID WP_000028424.1
Coordinates 915973..916146 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI239_RS04400 (KI239_04400) 910962..911390 + 429 WP_000934385.1 single-stranded DNA-binding protein -
KI239_RS04405 (KI239_04405) 911404..912078 + 675 WP_001124439.1 putative HNHc nuclease -
KI239_RS04410 (KI239_04410) 912075..912224 + 150 WP_001081076.1 hypothetical protein -
KI239_RS04415 (KI239_04415) 912217..912498 - 282 WP_000414755.1 hypothetical protein -
KI239_RS04420 (KI239_04420) 912564..913334 + 771 WP_000190253.1 conserved phage C-terminal domain-containing protein -
KI239_RS04425 (KI239_04425) 913344..914123 + 780 WP_000803062.1 ATP-binding protein -
KI239_RS04430 (KI239_04430) 914117..914275 + 159 WP_000256590.1 hypothetical protein -
KI239_RS04435 (KI239_04435) 914288..914509 + 222 WP_001123685.1 DUF3269 family protein -
KI239_RS04440 (KI239_04440) 914520..914924 + 405 WP_000049810.1 DUF1064 domain-containing protein -
KI239_RS04445 (KI239_04445) 914929..915114 + 186 WP_049317452.1 DUF3113 family protein -
KI239_RS04450 (KI239_04450) 915115..915471 + 357 WP_000029369.1 SA1788 family PVL leukocidin-associated protein -
KI239_RS04455 (KI239_04455) 915475..915717 + 243 WP_000131381.1 phi PVL orf 51-like protein -
KI239_RS04460 (KI239_04460) 915732..915983 + 252 WP_025174939.1 DUF1024 family protein Toxin
KI239_RS04465 (KI239_04465) 915973..916146 + 174 WP_000028424.1 hypothetical protein Antitoxin
KI239_RS04470 (KI239_04470) 916147..916428 + 282 WP_000454994.1 hypothetical protein -
KI239_RS04475 (KI239_04475) 916429..916590 + 162 WP_000889683.1 hypothetical protein -
KI239_RS04480 (KI239_04480) 916605..917138 + 534 WP_025920701.1 dUTP diphosphatase -
KI239_RS04485 (KI239_04485) 917175..917381 + 207 WP_000195827.1 DUF1381 domain-containing protein -
KI239_RS04490 (KI239_04490) 917378..917572 + 195 Protein_887 hypothetical protein -
KI239_RS04495 (KI239_04495) 917569..917772 + 204 WP_001072795.1 hypothetical protein -
KI239_RS04500 (KI239_04500) 917765..918001 + 237 WP_000608278.1 hypothetical protein -
KI239_RS04505 (KI239_04505) 917994..918167 + 174 WP_000595257.1 transcriptional activator RinB -
KI239_RS04510 (KI239_04510) 918168..918314 + 147 WP_000990005.1 hypothetical protein -
KI239_RS04515 (KI239_04515) 918338..918760 + 423 WP_000162701.1 RinA family phage transcriptional activator -
KI239_RS04520 (KI239_04520) 918948..919442 + 495 WP_001038244.1 terminase small subunit -
KI239_RS04525 (KI239_04525) 919445..920740 + 1296 WP_117172029.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - eta 902190..945745 43555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T204557 WP_025174939.1 NZ_CP076028:915732-915983 [Staphylococcus sp. MZ8]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T204557 NZ_CP100765:56035-56310 [Serratia nematodiphila]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTCGATAATCCCCGCCTGGGTGAAAGATTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGCTATGAGATACGTTATCAGGTGCAGCCGGCAGCGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT204557 WP_000028424.1 NZ_CP076028:915973-916146 [Staphylococcus sp. MZ8]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT204557 NZ_CP100765:55775-56035 [Serratia nematodiphila]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCGCGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCGGCCAGCCTGGACAGTGACGAG
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References