Detailed information of TA system TA204555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2532809..2533332
• Replicon: chromosome
• Accession: NZ_CP076027
• Organism: Staphylococcus sp. MZ7

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KI234_RS12590
• Protein ID: WP_045177693.1
• Coordinates: 2532809..2533075 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KI234_RS12595
• Protein ID: WP_000587618.1
• Coordinates: 2533075..2533332 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI234_RS12570 (KI234_12570)	2528115..2529302	-	1188	WP_045177690.1	MFS transporter	-
KI234_RS12575 (KI234_12575)	2529698..2530474	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
KI234_RS12580 (KI234_12580)	2530467..2531129	-	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
KI234_RS12585 (KI234_12585)	2531377..2532453	-	1077	WP_001076673.1	M42 family metallopeptidase	-
KI234_RS12590 (KI234_12590)	2532809..2533075	-	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
KI234_RS12595 (KI234_12595)	2533075..2533332	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI234_RS12600 (KI234_12600)	2533692..2534147	+	456	WP_000732090.1	YehR family lipoprotein	-
KI234_RS12605 (KI234_12605)	2534315..2535892	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KI234_RS12610 (KI234_12610)	2536087..2536836	+	750	WP_000072443.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T204555 WP_045177693.1 NZ_CP076027:c2533075-2532809 [Staphylococcus sp. MZ7]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T204555 NZ_CP100764:c4391211-4390789 [Serratia plymuthica]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGTTACTTTCGCTGCTGACCCACGGCGTTCTTATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCACGGCAGGGCGAGCTGCGTTTGCTGGCGAATAAGCGGTTAAGTTGGCACGGACAG
GAATGGTTGCTGGTAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGATACAGGGCAAAAAATG
CCGCCGGCTGTGGTTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT204555 WP_000587618.1 NZ_CP076027:c2533332-2533075 [Staphylococcus sp. MZ7]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT204555 NZ_CP100764:c4391458-4391192 [Serratia plymuthica]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGACATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGATCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2