Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2476268..2476785 Replicon chromosome
Accession NZ_CP076027
Organism Staphylococcus sp. MZ7

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KI234_RS12315 Protein ID WP_000113262.1
Coordinates 2476268..2476534 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KI234_RS12320 Protein ID WP_000584499.1
Coordinates 2476534..2476785 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI234_RS12290 (KI234_12290) 2471695..2472231 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KI234_RS12295 (KI234_12295) 2472464..2473288 - 825 WP_045177662.1 formate/nitrite transporter family protein -
KI234_RS12300 (KI234_12300) 2473505..2473687 - 183 WP_000230294.1 hypothetical protein -
KI234_RS12305 (KI234_12305) 2473771..2474238 - 468 WP_000153346.1 SRPBCC domain-containing protein -
KI234_RS12310 (KI234_12310) 2474424..2475974 - 1551 WP_045177665.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KI234_RS14010 2476162..2476233 - 72 WP_223200558.1 hypothetical protein -
KI234_RS12315 (KI234_12315) 2476268..2476534 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KI234_RS12320 (KI234_12320) 2476534..2476785 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KI234_RS12325 (KI234_12325) 2476950..2477051 - 102 WP_001791744.1 hypothetical protein -
KI234_RS12330 (KI234_12330) 2477058..2477657 - 600 WP_000162812.1 DsbA family protein -
KI234_RS12335 (KI234_12335) 2477676..2478038 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KI234_RS12340 (KI234_12340) 2478293..2479543 + 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
KI234_RS12345 (KI234_12345) 2479640..2480371 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KI234_RS12350 (KI234_12350) 2480368..2481087 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T204552 WP_000113262.1 NZ_CP076027:c2476534-2476268 [Staphylococcus sp. MZ7]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T204552 NZ_CP100764:2047444-2047540 [Serratia plymuthica]
AACAAGCCCTGCACAAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT204552 WP_000584499.1 NZ_CP076027:c2476785-2476534 [Staphylococcus sp. MZ7]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT204552 NZ_CP100764:c2047548-2047400 [Serratia plymuthica]
AACAAGTTAAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTTTGTGCAGGGCTTGTTCAGCCATGCACTTTAAGAGTAGCTTACCGCGCTAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References