Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1136694..1137108 | Replicon | chromosome |
| Accession | NZ_CP076027 | ||
| Organism | Staphylococcus sp. MZ7 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | KI234_RS05615 | Protein ID | WP_025174939.1 |
| Coordinates | 1136694..1136945 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KI234_RS05620 | Protein ID | WP_000028424.1 |
| Coordinates | 1136935..1137108 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI234_RS05565 (KI234_05565) | 1131870..1132541 | + | 672 | WP_138267805.1 | putative HNHc nuclease | - |
| KI234_RS05570 (KI234_05570) | 1132648..1133496 | - | 849 | WP_214983338.1 | DUF4393 domain-containing protein | - |
| KI234_RS05575 (KI234_05575) | 1133560..1134297 | + | 738 | WP_001668920.1 | conserved phage C-terminal domain-containing protein | - |
| KI234_RS05580 (KI234_05580) | 1134307..1135086 | + | 780 | WP_089557960.1 | ATP-binding protein | - |
| KI234_RS05585 (KI234_05585) | 1135080..1135238 | + | 159 | WP_072517142.1 | hypothetical protein | - |
| KI234_RS05590 (KI234_05590) | 1135251..1135472 | + | 222 | WP_001123685.1 | DUF3269 family protein | - |
| KI234_RS05595 (KI234_05595) | 1135483..1135886 | + | 404 | Protein_1104 | DUF1064 domain-containing protein | - |
| KI234_RS05600 (KI234_05600) | 1135891..1136076 | + | 186 | WP_049317452.1 | DUF3113 family protein | - |
| KI234_RS05605 (KI234_05605) | 1136077..1136433 | + | 357 | WP_000029369.1 | SA1788 family PVL leukocidin-associated protein | - |
| KI234_RS05610 (KI234_05610) | 1136437..1136679 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| KI234_RS05615 (KI234_05615) | 1136694..1136945 | + | 252 | WP_025174939.1 | DUF1024 family protein | Toxin |
| KI234_RS05620 (KI234_05620) | 1136935..1137108 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| KI234_RS05625 (KI234_05625) | 1137109..1137390 | + | 282 | WP_000454994.1 | hypothetical protein | - |
| KI234_RS05630 (KI234_05630) | 1137391..1137552 | + | 162 | WP_000889683.1 | hypothetical protein | - |
| KI234_RS05635 (KI234_05635) | 1137567..1138100 | + | 534 | WP_214983340.1 | dUTP diphosphatase | - |
| KI234_RS05640 (KI234_05640) | 1138137..1138424 | + | 288 | WP_000195801.1 | DUF1381 domain-containing protein | - |
| KI234_RS05645 (KI234_05645) | 1138417..1138653 | + | 237 | WP_000608278.1 | hypothetical protein | - |
| KI234_RS05650 (KI234_05650) | 1138646..1139032 | + | 387 | WP_000592202.1 | hypothetical protein | - |
| KI234_RS05655 (KI234_05655) | 1139029..1139202 | + | 174 | WP_015988676.1 | transcriptional activator RinB | - |
| KI234_RS05660 (KI234_05660) | 1139203..1139604 | + | 402 | WP_000286968.1 | hypothetical protein | - |
| KI234_RS05665 (KI234_05665) | 1139956..1140450 | + | 495 | WP_000594085.1 | hypothetical protein | - |
| KI234_RS05670 (KI234_05670) | 1140443..1141651 | + | 1209 | WP_214983342.1 | PBSX family phage terminase large subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1123393..1166300 | 42907 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9361.22 Da Isoelectric Point: 3.8464
>T204546 WP_025174939.1 NZ_CP076027:1136694-1136945 [Staphylococcus sp. MZ7]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T204546 NZ_CP100764:513560-513835 [Serratia plymuthica]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGCCTGCTGGAGCATCCTGAGTTAGGTAAGACCTGGCATG
GGAAGGCGCGTAAGCTGCTTATTAATAAGGCCTCTCTGTTGCTGGTATATATCATCGTCGATGATGTTATTAAGGTTTTC
GCGATTGCTCACCAGCGCGAGAAATTTCCAAACTAG
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGCCTGCTGGAGCATCCTGAGTTAGGTAAGACCTGGCATG
GGAAGGCGCGTAAGCTGCTTATTAATAAGGCCTCTCTGTTGCTGGTATATATCATCGTCGATGATGTTATTAAGGTTTTC
GCGATTGCTCACCAGCGCGAGAAATTTCCAAACTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT204546 WP_000028424.1 NZ_CP076027:1136935-1137108 [Staphylococcus sp. MZ7]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT204546 NZ_CP100764:513264-513551 [Serratia plymuthica]
ATGGAAAGTCGTATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCTGAAGCTAAAGGGACGAC
ATTAAGTGAAGCCTGTCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCAGCGGAAGAGCACGAAAACTGGTTGA
AAGATAAGGTAGATGCAGCTTTTTCCCGTCTGCATGAGGGCAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATCAGAGCGAAATACGACCGAAAATAG
ATGGAAAGTCGTATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCTGAAGCTAAAGGGACGAC
ATTAAGTGAAGCCTGTCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCAGCGGAAGAGCACGAAAACTGGTTGA
AAGATAAGGTAGATGCAGCTTTTTCCCGTCTGCATGAGGGCAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATCAGAGCGAAATACGACCGAAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|