Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 873939..874353 Replicon chromosome
Accession NZ_CP076027
Organism Staphylococcus sp. MZ7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI234_RS04220 Protein ID WP_025174939.1
Coordinates 873939..874190 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI234_RS04225 Protein ID WP_000028424.1
Coordinates 874180..874353 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI234_RS04160 (KI234_04160) 869169..869597 + 429 WP_000934385.1 single-stranded DNA-binding protein -
KI234_RS04165 (KI234_04165) 869611..870285 + 675 WP_001124439.1 putative HNHc nuclease -
KI234_RS04170 (KI234_04170) 870282..870431 + 150 WP_001081076.1 hypothetical protein -
KI234_RS04175 (KI234_04175) 870424..870705 - 282 WP_000414755.1 hypothetical protein -
KI234_RS04180 (KI234_04180) 870771..871541 + 771 WP_000190253.1 conserved phage C-terminal domain-containing protein -
KI234_RS04185 (KI234_04185) 871551..872330 + 780 WP_000803062.1 ATP-binding protein -
KI234_RS04190 (KI234_04190) 872324..872482 + 159 WP_000256590.1 hypothetical protein -
KI234_RS04195 (KI234_04195) 872495..872716 + 222 WP_001123685.1 DUF3269 family protein -
KI234_RS04200 (KI234_04200) 872727..873131 + 405 WP_000049810.1 DUF1064 domain-containing protein -
KI234_RS04205 (KI234_04205) 873136..873321 + 186 WP_049317452.1 DUF3113 family protein -
KI234_RS04210 (KI234_04210) 873322..873678 + 357 WP_000029369.1 SA1788 family PVL leukocidin-associated protein -
KI234_RS04215 (KI234_04215) 873682..873924 + 243 WP_000131381.1 phi PVL orf 51-like protein -
KI234_RS04220 (KI234_04220) 873939..874190 + 252 WP_025174939.1 DUF1024 family protein Toxin
KI234_RS04225 (KI234_04225) 874180..874353 + 174 WP_000028424.1 hypothetical protein Antitoxin
KI234_RS04230 (KI234_04230) 874354..874635 + 282 WP_000454994.1 hypothetical protein -
KI234_RS04235 (KI234_04235) 874636..874797 + 162 WP_000889683.1 hypothetical protein -
KI234_RS04240 (KI234_04240) 874812..875345 + 534 WP_025920701.1 dUTP diphosphatase -
KI234_RS04245 (KI234_04245) 875382..875588 + 207 WP_000195827.1 DUF1381 domain-containing protein -
KI234_RS04250 (KI234_04250) 875585..875779 + 195 Protein_836 hypothetical protein -
KI234_RS04255 (KI234_04255) 875776..875979 + 204 WP_001072795.1 hypothetical protein -
KI234_RS04260 (KI234_04260) 875972..876208 + 237 WP_000608278.1 hypothetical protein -
KI234_RS04265 (KI234_04265) 876201..876374 + 174 WP_000595257.1 transcriptional activator RinB -
KI234_RS04270 (KI234_04270) 876375..876521 + 147 WP_000990005.1 hypothetical protein -
KI234_RS04275 (KI234_04275) 876545..876967 + 423 WP_000162701.1 RinA family phage transcriptional activator -
KI234_RS04280 (KI234_04280) 877155..877649 + 495 WP_001038244.1 terminase small subunit -
KI234_RS04285 (KI234_04285) 877652..878947 + 1296 WP_117172029.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - eta 859781..903952 44171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T204545 WP_025174939.1 NZ_CP076027:873939-874190 [Staphylococcus sp. MZ7]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T204545 NZ_CP100764:57564-57839 [Serratia plymuthica]
ATGGAATTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGATTTTCTTGCCCCGGTTAACCGTACTGC
CGCAGCTAACACGATACAGGCTTTGGTTGCAGCACCTAAGGTACTGCGTGATAACCCCCGTATTGGCGAGAAACTGGATG
AATTTATGCCGCAGGAGGTGAGGCGTATCCTCGTCGGTCATTATGAAATGCGCTACCAACTTCAATCCTCAACAATTTAT
GTCCTGCGTATTTGGCATACGCGCGAAGAGCGTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT204545 WP_000028424.1 NZ_CP076027:874180-874353 [Staphylococcus sp. MZ7]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT204545 NZ_CP100764:57304-57564 [Serratia plymuthica]
ATGAATACTAAAGTCATCACCGCACATGTGCCGTTACCCTTAGCGGACAAAGTTGATGAGATGGCCGCTAAACTGGAACG
TTCGCGCGGATGGATCATTAAGCAGGCCCTTGCCGCATGGCTCGATCAAGAAGAAGAACGTCGCCGTTTAACATTGGAGG
CCCTCGCCGATGTCGAACAGCAAAATATCATCGACCATGAATCGGTAGAAACCTGGGCCGTAAGCCTGAGCAGCGATAAG
CCTTTACCGGTACCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References