Detailed information of TA system TA204543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2509184..2509707
• Replicon: chromosome
• Accession: NZ_CP076026
• Organism: Staphylococcus sp. MZ3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KI230_RS12380
• Protein ID: WP_045177693.1
• Coordinates: 2509184..2509450 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KI230_RS12385
• Protein ID: WP_000587618.1
• Coordinates: 2509450..2509707 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI230_RS12360 (KI230_12360)	2504490..2505677	-	1188	WP_045177690.1	MFS transporter	-
KI230_RS12365 (KI230_12365)	2506073..2506849	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
KI230_RS12370 (KI230_12370)	2506842..2507504	-	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
KI230_RS12375 (KI230_12375)	2507752..2508828	-	1077	WP_001076673.1	M42 family metallopeptidase	-
KI230_RS12380 (KI230_12380)	2509184..2509450	-	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
KI230_RS12385 (KI230_12385)	2509450..2509707	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI230_RS12390 (KI230_12390)	2510067..2510522	+	456	WP_000732090.1	YehR family lipoprotein	-
KI230_RS12395 (KI230_12395)	2510690..2512267	-	1578	WP_214958278.1	FMN-binding glutamate synthase family protein	-
KI230_RS12400 (KI230_12400)	2512462..2513211	+	750	WP_000072443.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T204543 WP_045177693.1 NZ_CP076026:c2509450-2509184 [Staphylococcus sp. MZ3]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T204543 NZ_CP100755:3844106-3844381 [Alcaligenes sp. NLF5-7]
ATGAAATTAAAGTGGACTAGTAAGGCGCTTTCTGATTTAGAGCGCCTGTATGAGTTTTTGGCCGTGGTGAATAAACCTGC
TGCTGCTCGTGCCGTGCAAAAACTGACCAAGGCCCCGAGCATTTTACTGAGCAATCCACGCATTGGTGAGCAGCTCTTTA
TGTTTGAGCCACGTGAGGTAAGGCGAATTCTGGTCGGAGAGTATGAAATTCGTTATGAGCTTCAGGATTCGTTTATCTAC
GTGCTTCGGATATGGCACACCAGAGAAAATCGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT204543 WP_000587618.1 NZ_CP076026:c2509707-2509450 [Staphylococcus sp. MZ3]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT204543 NZ_CP100755:3843840-3844106 [Alcaligenes sp. NLF5-7]
ATGACAGCAGCAACTAAGGTACTTACCGCACATGTACCGCTTCCGTTGGCTACCAAGGTAGACCAGATGGCTGCTCGTCT
TGATCGCTCGCGTGGCTGGATCATGAAGCAGGCTCTTTCAGCCTGGATAGCCCAAGAAGAGGAGCGCACGAGACTGACCC
AAGAGGCGTTGGTTGATGTCGACAAGGGTTGTGTCATTGACCACCAAGCTGTACAGGCTTGGGCTGAGAGTCTTGGTACT
GAGCAGCAGTTGCCACTGCCACGCTGA

Structures

Antitoxin

• AlphaFold DB: T1YBB2