Detailed information of TA system TA204541

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2477984..2478168
• Replicon: chromosome
• Accession: NZ_CP076026
• Organism: Staphylococcus sp. MZ3

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KI230_RS12240
• Protein ID: WP_000482647.1
• Coordinates: 2478061..2478168 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2477984..2478044 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI230_RS12225 (KI230_12225)	2473435..2473602	-	168	WP_001790576.1	hypothetical protein	-
KI230_RS12230 (KI230_12230)	2473833..2475566	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
KI230_RS12235 (KI230_12235)	2475591..2477354	-	1764	WP_006191000.1	ABC transporter ATP-binding protein	-
-	2477984..2478044	+	61	-	-	Antitoxin
KI230_RS12240 (KI230_12240)	2478061..2478168	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KI230_RS12245 (KI230_12245)	2478302..2478688	-	387	WP_000779360.1	flippase GtxA	-
KI230_RS12250 (KI230_12250)	2478956..2480098	+	1143	WP_001176863.1	glycerate kinase	-
KI230_RS12255 (KI230_12255)	2480158..2480817	+	660	WP_000831298.1	membrane protein	-
KI230_RS12260 (KI230_12260)	2480999..2482210	+	1212	WP_214958277.1	multidrug effflux MFS transporter	-
KI230_RS12265 (KI230_12265)	2482333..2482806	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T204541 WP_000482647.1 NZ_CP076026:c2478168-2478061 [Staphylococcus sp. MZ3]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T204541 NZ_CP100755:c1313975-1313055 [Alcaligenes sp. NLF5-7]
ATGAATCCCCTGCCTGGCACCTTGCCGCTTTTATCCGCCCGGGAGACGCGCTATCTGCAGGCCTGTCTGCCCTTGTCGAC
CGTAGACATCGGTCGTGGCCGACAGGTGGCGGTGCGATGCGCGGGCGACGGTGAGCAATGGGTCGTTTGCTTGCACGGCA
TCGGTTCGGGCTCGGCGTCCTGGTTGCGGGTGGCACAGCAATTGCCACCGGGCCTGCGCTTGCTGGCTTGGGATGCTCCC
GGTTATGGCTTGTCTACTCCTCTGGAAATGGACAAGCCCACGGCGCTGGACTATGCCCGGCGTCTGCAGGAACTGCTGCA
TGTTCTGGAAGTGAAGGATTTTGTGCTGGTCGGGCACTCCTTGGGTGCCTTGATGGCGGGCGCCTATGCCCGTCATCTTG
ATCAGGGAGAGATGCAGGCGTTGTTCCTGATGAGCCCTGCAATTGGGTATGGACGCCCGGGTTTGGAACAGCGCCGTCAG
GCAGTGTGGGATCAGCGTATGGCGCAGGTGGCGTCGGGTGATATGGGCTTGATGGCTCGTCAGCGTCACCAGCGATTGCT
GTCGGAGCAGGCTACTTCCGAAAACCGGGAGTTGGTGTTGTGGATTATGGCCAGTCTGCACCTGGCGGGCTATCAGCAAG
CTGTGCAGATGTTGTGCCAGGAAGACCTGCTAACCTACCTGCCTCTTTCCAGCAGCGTGCCTGTCGCAGTGAGTTGTGGC
GAAGTGGATGTGGTGACAACTCCTGAGGCGTGCGCCGGGGTGGCGCGGGCTTGTTCCCAACATTTACAACTGGTTCCCCA
AGCGGGACATGCCAGTTATGTCGAGCAGCCTGGTGCCATGCTGGAAGCCTTGCAATCTTTGCTGGGCCAGACGCAAGCCT
TGCGTTCCGTGGCCACGACCAGGAGTAGTCATGAGCAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT204541 NZ_CP076026:2477984-2478044 [Staphylococcus sp. MZ3]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin