Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2452643..2453160 | Replicon | chromosome |
| Accession | NZ_CP076026 | ||
| Organism | Staphylococcus sp. MZ3 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KI230_RS12105 | Protein ID | WP_000113262.1 |
| Coordinates | 2452643..2452909 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KI230_RS12110 | Protein ID | WP_000584499.1 |
| Coordinates | 2452909..2453160 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI230_RS12080 (KI230_12080) | 2448070..2448606 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KI230_RS12085 (KI230_12085) | 2448839..2449663 | - | 825 | WP_045177662.1 | formate/nitrite transporter family protein | - |
| KI230_RS12090 (KI230_12090) | 2449880..2450062 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| KI230_RS12095 (KI230_12095) | 2450146..2450613 | - | 468 | WP_000153346.1 | SRPBCC domain-containing protein | - |
| KI230_RS12100 (KI230_12100) | 2450799..2452349 | - | 1551 | WP_045177665.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KI230_RS13805 | 2452537..2452608 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| KI230_RS12105 (KI230_12105) | 2452643..2452909 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KI230_RS12110 (KI230_12110) | 2452909..2453160 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KI230_RS12115 (KI230_12115) | 2453325..2453426 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| KI230_RS12120 (KI230_12120) | 2453433..2454032 | - | 600 | WP_000162812.1 | DsbA family protein | - |
| KI230_RS12125 (KI230_12125) | 2454051..2454413 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KI230_RS12130 (KI230_12130) | 2454668..2455918 | + | 1251 | WP_001012241.1 | FemA/FemB family glycyltransferase FmhA | - |
| KI230_RS12135 (KI230_12135) | 2456015..2456746 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KI230_RS12140 (KI230_12140) | 2456743..2457462 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T204540 WP_000113262.1 NZ_CP076026:c2452909-2452643 [Staphylococcus sp. MZ3]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T204540 NZ_CP100755:30746-31009 [Alcaligenes sp. NLF5-7]
ATGACTGACCGTTTGTTATGCTGGACTGACGCTGCCTGGATTGACTATGTGTATTGGCAAGGCCAGGACCGCAAGACATT
GAAGCGTATCAACAGACTGATAGAGGAAGTACGACGTGCGCCATTCGATGGCATAGGCAAACCTGAAGCGCTTAAAGAAA
ATCTGTCCGGCTTTTGGTCAAGACGCATTGATGACACGAATCGCCTGGTCTATGCCGTAGACAAGGCAAGCATCACCATC
ATTTCTTGTCGTTATCATTATTAA
ATGACTGACCGTTTGTTATGCTGGACTGACGCTGCCTGGATTGACTATGTGTATTGGCAAGGCCAGGACCGCAAGACATT
GAAGCGTATCAACAGACTGATAGAGGAAGTACGACGTGCGCCATTCGATGGCATAGGCAAACCTGAAGCGCTTAAAGAAA
ATCTGTCCGGCTTTTGGTCAAGACGCATTGATGACACGAATCGCCTGGTCTATGCCGTAGACAAGGCAAGCATCACCATC
ATTTCTTGTCGTTATCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT204540 WP_000584499.1 NZ_CP076026:c2453160-2452909 [Staphylococcus sp. MZ3]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT204540 NZ_CP100755:30499-30753 [Alcaligenes sp. NLF5-7]
ATGAAAATCATCTCGTTTTCAGAAGCGCGCAACAGCTTGAAAGCTGTACTGGATAGCGTAGTCGATGACGCCAGCACCAC
CATCATCACGCGTCGTGATGCGGAAGACGCTGTAGTCATGTCACTCGATTACTACAACAGCTTGATGGAAACCGTCCATC
TGCTGCGCTCCCCCGCTAATGCGGAACACCTGAGCCGCTCTATCGAACAATATCGTGCTGGCAAAGCCATGCCACGCGAG
CTGAGCGATGACTGA
ATGAAAATCATCTCGTTTTCAGAAGCGCGCAACAGCTTGAAAGCTGTACTGGATAGCGTAGTCGATGACGCCAGCACCAC
CATCATCACGCGTCGTGATGCGGAAGACGCTGTAGTCATGTCACTCGATTACTACAACAGCTTGATGGAAACCGTCCATC
TGCTGCGCTCCCCCGCTAATGCGGAACACCTGAGCCGCTCTATCGAACAATATCGTGCTGGCAAAGCCATGCCACGCGAG
CTGAGCGATGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|