Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2971372..2972020 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MT_RS13955 Protein ID WP_003899414.1
Coordinates 2971372..2971695 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MT_RS13960 Protein ID WP_003899415.1
Coordinates 2971775..2972020 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS13925 2966695..2967693 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MT_RS13930 2967707..2968171 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MT_RS13935 2968159..2968410 + 252 WP_003908028.1 hypothetical protein -
MT_RS13940 2968581..2970020 - 1440 WP_003899411.1 phage major capsid protein -
MT_RS13945 2970028..2970561 - 534 WP_003899412.1 HK97 family phage prohead protease -
MT_RS21490 2970714..2971205 - 492 WP_003900541.1 phage terminase small subunit P27 family -
MT_RS13955 2971372..2971695 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MT_RS13960 2971775..2972020 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MT_RS13965 2972017..2973444 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MT_RS13970 2973446..2973838 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MT_RS13975 2973835..2974095 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
MT_RS13980 2974112..2974474 - 363 WP_003900543.1 hypothetical protein -
MT_RS13985 2974477..2975604 - 1128 WP_003899420.1 site-specific integrase -
MT_RS13990 2975749..2975976 - 228 WP_003899421.1 hypothetical protein -
MT_RS21495 2975973..2976362 - 390 WP_003899422.1 hypothetical protein -
MT_RS13995 2976268..2976540 + 273 WP_003900544.1 hypothetical protein -
MT_RS14000 2976639..2976872 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2966695..2975604 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T20454 WP_003899414.1 NC_002755:c2971695-2971372 [Mycobacterium tuberculosis CDC1551]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T20454 NC_002755:c2971695-2971372 [Mycobacterium tuberculosis CDC1551]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT20454 WP_003899415.1 NC_002755:c2972020-2971775 [Mycobacterium tuberculosis CDC1551]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT20454 NC_002755:c2972020-2971775 [Mycobacterium tuberculosis CDC1551]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References