Detailed information of TA system TA204535

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1909110..1909292
• Replicon: chromosome
• Accession: NZ_CP076026
• Organism: Staphylococcus sp. MZ3

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KI230_RS09180
• Protein ID: WP_001801861.1
• Coordinates: 1909110..1909205 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1909233..1909292 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI230_RS09140 (KI230_09140)	1904724..1905317	+	594	WP_000768323.1	hypothetical protein	-
KI230_RS09145 (KI230_09145)	1905365..1905718	+	354	WP_214958257.1	cystatin-like fold lipoprotein	-
KI230_RS09150 (KI230_09150)	1905831..1906337	+	507	WP_204177705.1	helix-turn-helix domain-containing protein	-
KI230_RS09155 (KI230_09155)	1906303..1906794	+	492	WP_204177707.1	IS30 family transposase	-
KI230_RS09160 (KI230_09160)	1907067..1907287	-	221	Protein_1813	hypothetical protein	-
KI230_RS09165 (KI230_09165)	1907590..1907766	-	177	WP_000375477.1	hypothetical protein	-
KI230_RS09170 (KI230_09170)	1907777..1908160	-	384	WP_000070811.1	hypothetical protein	-
KI230_RS09175 (KI230_09175)	1908764..1908907	-	144	WP_001549059.1	transposase	-
KI230_RS09180 (KI230_09180)	1909110..1909205	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1909233..1909292	-	60	-	-	Antitoxin
KI230_RS09185 (KI230_09185)	1909328..1909429	+	102	WP_001791893.1	hypothetical protein	-
KI230_RS09190 (KI230_09190)	1909407..1909583	-	177	Protein_1819	transposase	-
KI230_RS09195 (KI230_09195)	1909777..1910154	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1866178..1931398	65220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T204535 WP_001801861.1 NZ_CP076026:1909110-1909205 [Staphylococcus sp. MZ3]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T204535 NZ_CP100753:3047297-3047581 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCGGTGCTGGTTAACCCCCACATCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTATATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT204535 NZ_CP076026:c1909292-1909233 [Staphylococcus sp. MZ3]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin