Detailed information of TA system TA204532

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2496882..2497405
• Replicon: chromosome
• Accession: NZ_CP076025
• Organism: Staphylococcus sp. MZ1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KI229_RS12345
• Protein ID: WP_045177693.1
• Coordinates: 2496882..2497148 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KI229_RS12350
• Protein ID: WP_000587618.1
• Coordinates: 2497148..2497405 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI229_RS12325 (KI229_12325)	2492188..2493375	-	1188	WP_045177690.1	MFS transporter	-
KI229_RS12330 (KI229_12330)	2493771..2494547	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
KI229_RS12335 (KI229_12335)	2494540..2495202	-	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
KI229_RS12340 (KI229_12340)	2495450..2496526	-	1077	WP_001076673.1	M42 family metallopeptidase	-
KI229_RS12345 (KI229_12345)	2496882..2497148	-	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
KI229_RS12350 (KI229_12350)	2497148..2497405	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KI229_RS12355 (KI229_12355)	2497765..2498220	+	456	WP_000732090.1	YehR family lipoprotein	-
KI229_RS12360 (KI229_12360)	2498388..2499965	-	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KI229_RS12365 (KI229_12365)	2500160..2500909	+	750	WP_000072443.1	CPBP family lipoprotein N-acylation protein LnsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T204532 WP_045177693.1 NZ_CP076025:c2497148-2496882 [Staphylococcus sp. MZ1]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T204532 NZ_CP100753:1324836-1325189 [Serratia marcescens]
GTGTGGGAAATTAAAACAACGGATGCATTTGATCATTGGTTAAGATCACTCAGCGATGCCGACCGGGCCTGCGTGCTTGC
TGCATTGATGGTCCTGCGGGAAAAAGGGCCCGGCTTGCCCAGGCCCTATGCCGATACGGTTAAAGGCTCGCGTTACAGCA
ACATGAAAGAGCTGCGTATTCAGAGCCGTGGCGAACCGTTGCGGGCATTTTTCGCCTTCGATCCGTACCGTATCGGCATG
GTGCTTTGCGCGGGCAATAAAGCGGGCGATGAAAAACGTTTTTACGATCGAATGCTGCAGATTGCCGATCGGGAATTCAC
GAATTGGCTGAACACACTAAAAGAGAAGGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT204532 WP_000587618.1 NZ_CP076025:c2497405-2497148 [Staphylococcus sp. MZ1]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT204532 NZ_CP100753:1325194-1325496 [Serratia marcescens]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGAGGAAAAGCCCGAGGTCGTGGCCGAAGCGCAGGCAATGGCGACGGACAT
TATGCTGAACATCCATCTTGCCGAGCTGCGCGAGAAGGTGCAGAAAACCCAGGTTGAAATGGCGCAGGCGCTGGGTATCA
GGCAACCGACCGTCGCCGTGATGGAAAAACCGGGCCGCGATCTGAAACTGTCTTCGCTCAAACGCTATGTTGAGGCGGCG
GGCGGCAAACTGCGCCTGGATGTCGAACTGCCGGACGGTTCGCACTACGAATTTGTGCTGTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2