Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2440342..2440859 Replicon chromosome
Accession NZ_CP076025
Organism Staphylococcus sp. MZ1

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KI229_RS12070 Protein ID WP_000113262.1
Coordinates 2440342..2440608 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KI229_RS12075 Protein ID WP_000584499.1
Coordinates 2440608..2440859 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI229_RS12045 (KI229_12045) 2435769..2436305 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KI229_RS12050 (KI229_12050) 2436538..2437362 - 825 WP_045177662.1 formate/nitrite transporter family protein -
KI229_RS12055 (KI229_12055) 2437579..2437761 - 183 WP_000230294.1 hypothetical protein -
KI229_RS12060 (KI229_12060) 2437845..2438312 - 468 WP_000153346.1 SRPBCC domain-containing protein -
KI229_RS12065 (KI229_12065) 2438498..2440048 - 1551 WP_045177665.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KI229_RS13980 2440236..2440307 - 72 WP_223200558.1 hypothetical protein -
KI229_RS12070 (KI229_12070) 2440342..2440608 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KI229_RS12075 (KI229_12075) 2440608..2440859 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KI229_RS12080 (KI229_12080) 2441024..2441125 - 102 WP_001791744.1 hypothetical protein -
KI229_RS12085 (KI229_12085) 2441132..2441731 - 600 WP_000162812.1 DsbA family protein -
KI229_RS12090 (KI229_12090) 2441750..2442112 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KI229_RS12095 (KI229_12095) 2442367..2443617 + 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
KI229_RS12100 (KI229_12100) 2443714..2444445 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KI229_RS12105 (KI229_12105) 2444442..2445161 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T204529 WP_000113262.1 NZ_CP076025:c2440608-2440342 [Staphylococcus sp. MZ1]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T204529 NZ_CP100753:521997-522419 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGATCGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGACTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAATGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAACAAGGTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT204529 WP_000584499.1 NZ_CP076025:c2440859-2440608 [Staphylococcus sp. MZ1]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT204529 NZ_CP100753:521750-522016 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGATGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References