Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 866529..866943 Replicon chromosome
Accession NZ_CP076025
Organism Staphylococcus sp. MZ1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI229_RS04200 Protein ID WP_025174939.1
Coordinates 866529..866780 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI229_RS04205 Protein ID WP_000028424.1
Coordinates 866770..866943 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI229_RS04140 (KI229_04140) 861759..862187 + 429 WP_000934385.1 single-stranded DNA-binding protein -
KI229_RS04145 (KI229_04145) 862201..862875 + 675 WP_001124439.1 putative HNHc nuclease -
KI229_RS04150 (KI229_04150) 862872..863021 + 150 WP_001081076.1 hypothetical protein -
KI229_RS04155 (KI229_04155) 863014..863295 - 282 WP_000414755.1 hypothetical protein -
KI229_RS04160 (KI229_04160) 863361..864131 + 771 WP_000190253.1 conserved phage C-terminal domain-containing protein -
KI229_RS04165 (KI229_04165) 864141..864920 + 780 WP_000803062.1 ATP-binding protein -
KI229_RS04170 (KI229_04170) 864914..865072 + 159 WP_000256590.1 hypothetical protein -
KI229_RS04175 (KI229_04175) 865085..865306 + 222 WP_001123685.1 DUF3269 family protein -
KI229_RS04180 (KI229_04180) 865317..865721 + 405 WP_000049810.1 DUF1064 domain-containing protein -
KI229_RS04185 (KI229_04185) 865726..865911 + 186 WP_049317452.1 DUF3113 family protein -
KI229_RS04190 (KI229_04190) 865912..866268 + 357 WP_000029369.1 SA1788 family PVL leukocidin-associated protein -
KI229_RS04195 (KI229_04195) 866272..866514 + 243 WP_000131381.1 phi PVL orf 51-like protein -
KI229_RS04200 (KI229_04200) 866529..866780 + 252 WP_025174939.1 DUF1024 family protein Toxin
KI229_RS04205 (KI229_04205) 866770..866943 + 174 WP_000028424.1 hypothetical protein Antitoxin
KI229_RS04210 (KI229_04210) 866944..867225 + 282 WP_000454994.1 hypothetical protein -
KI229_RS04215 (KI229_04215) 867226..867387 + 162 WP_000889683.1 hypothetical protein -
KI229_RS04220 (KI229_04220) 867402..867935 + 534 WP_025920701.1 dUTP diphosphatase -
KI229_RS04225 (KI229_04225) 867972..868178 + 207 WP_000195827.1 DUF1381 domain-containing protein -
KI229_RS04230 (KI229_04230) 868175..868369 + 195 Protein_830 hypothetical protein -
KI229_RS04235 (KI229_04235) 868366..868569 + 204 WP_001072795.1 hypothetical protein -
KI229_RS04240 (KI229_04240) 868562..868798 + 237 WP_000608278.1 hypothetical protein -
KI229_RS04245 (KI229_04245) 868791..868964 + 174 WP_000595257.1 transcriptional activator RinB -
KI229_RS04250 (KI229_04250) 868965..869111 + 147 WP_000990005.1 hypothetical protein -
KI229_RS04255 (KI229_04255) 869135..869557 + 423 WP_000162701.1 RinA family phage transcriptional activator -
KI229_RS04260 (KI229_04260) 869745..870239 + 495 WP_001038244.1 terminase small subunit -
KI229_RS04265 (KI229_04265) 870242..871537 + 1296 WP_117172029.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - eta 852986..896542 43556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T204523 WP_025174939.1 NZ_CP076025:866529-866780 [Staphylococcus sp. MZ1]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T204523 NZ_CP100747:4459522-4459833 [Salmonella enterica subsp. enterica serovar Montevideo]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT204523 WP_000028424.1 NZ_CP076025:866770-866943 [Staphylococcus sp. MZ1]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT204523 NZ_CP100747:4459830-4460276 [Salmonella enterica subsp. enterica serovar Montevideo]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References