Detailed information of TA system TA204407

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1904853..1905111
• Replicon: chromosome
• Accession: NZ_CP075852
• Organism: Escherichia coli strain S19-651

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JFY28_RS09435
• Protein ID: WP_000809168.1
• Coordinates: 1904959..1905111 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1904853..1904910 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFY28_RS09415	1899880..1901232	+	1353	Protein_1851	fimbria/pilus outer membrane usher protein	-
JFY28_RS09420	1901245..1902204	+	960	WP_000871671.1	hypothetical protein	-
JFY28_RS09425	1902242..1903141	-	900	WP_001300855.1	transcriptional activator NhaR	-
JFY28_RS09430	1903207..1904373	-	1167	WP_000681359.1	Na+/H+ antiporter NhaA	-
-	1904853..1904910	-	58	-	-	Antitoxin
JFY28_RS09435	1904959..1905111	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JFY28_RS09440	1905215..1906345	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
JFY28_RS09445	1906434..1908350	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JFY28_RS09450	1908727..1909131	+	405	WP_000843559.1	DUF2541 family protein	-
JFY28_RS09455	1909157..1909870	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T204407 WP_000809168.1 NZ_CP075852:1904959-1905111 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T204407 NZ_CP100718:c4336307-4336023 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCCTGGTGTACCAGGTTCGGGATGAAGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT204407 NZ_CP075852:c1904910-1904853 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin