Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2283513..2284206 Replicon chromosome
Accession NZ_CP075737
Organism Escherichia coli strain CPF6

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KKZ13_RS10880 Protein ID WP_000415584.1
Coordinates 2283910..2284206 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KKZ13_RS10875 Protein ID WP_000650107.1
Coordinates 2283513..2283908 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ13_RS10865 (2279377) 2279377..2281635 - 2259 WP_088213288.1 DNA topoisomerase IV subunit A -
KKZ13_RS10870 (2281773) 2281773..2283380 - 1608 WP_088213289.1 ABC transporter substrate-binding protein -
KKZ13_RS10875 (2283513) 2283513..2283908 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KKZ13_RS10880 (2283910) 2283910..2284206 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KKZ13_RS10885 (2284411) 2284411..2284893 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KKZ13_RS10890 (2284946) 2284946..2285338 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KKZ13_RS10895 (2285490) 2285490..2286149 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KKZ13_RS10900 (2286146) 2286146..2287495 + 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
KKZ13_RS10905 (2287541) 2287541..2287873 - 333 WP_000917684.1 DUF2645 family protein -
KKZ13_RS10910 (2288192) 2288192..2288773 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KKZ13_RS10915 (2288804) 2288804..2289118 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T204384 WP_000415584.1 NZ_CP075737:c2284206-2283910 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T204384 NZ_CP100715:838577-838990 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT204384 WP_000650107.1 NZ_CP075737:c2283908-2283513 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT204384 NZ_CP100715:838330-838596 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References