Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2382083..2382721 Replicon chromosome
Accession NZ_CP075722
Organism Escherichia coli strain CPE35

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag KKZ10_RS11575 Protein ID WP_001447010.1
Coordinates 2382545..2382721 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KKZ10_RS11570 Protein ID WP_001270286.1
Coordinates 2382083..2382499 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ10_RS11550 (2377235) 2377235..2378176 - 942 WP_001251304.1 ABC transporter permease -
KKZ10_RS11555 (2378177) 2378177..2379190 - 1014 WP_047609422.1 ABC transporter ATP-binding protein -
KKZ10_RS11560 (2379208) 2379208..2380353 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
KKZ10_RS11565 (2380598) 2380598..2382004 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KKZ10_RS11570 (2382083) 2382083..2382499 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KKZ10_RS11575 (2382545) 2382545..2382721 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KKZ10_RS11580 (2382943) 2382943..2383173 + 231 WP_000494244.1 YncJ family protein -
KKZ10_RS11585 (2383265) 2383265..2385226 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KKZ10_RS11590 (2385299) 2385299..2385835 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KKZ10_RS11595 (2385927) 2385927..2387102 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2387142..2388290 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T204326 WP_001447010.1 NZ_CP075722:c2382721-2382545 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T204326 NZ_CP100698:c4058388-4058080 [Salmonella enterica subsp. enterica serovar Agona]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGATGGGTTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT204326 WP_001270286.1 NZ_CP075722:c2382499-2382083 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT204326 NZ_CP100698:c4058630-4058391 [Salmonella enterica subsp. enterica serovar Agona]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTAGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCTGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References