Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1801756..1802258 | Replicon | chromosome |
| Accession | NZ_CP075722 | ||
| Organism | Escherichia coli strain CPE35 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KKZ10_RS08575 | Protein ID | WP_000767829.1 |
| Coordinates | 1802004..1802258 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KKZ10_RS08570 | Protein ID | WP_001259255.1 |
| Coordinates | 1801756..1802007 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KKZ10_RS08545 (1796933) | 1796933..1798000 | - | 1068 | WP_000080055.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KKZ10_RS08550 (1798000) | 1798000..1799070 | - | 1071 | WP_000108933.1 | histidinol-phosphate transaminase | - |
| KKZ10_RS08555 (1799067) | 1799067..1800371 | - | 1305 | WP_001352244.1 | histidinol dehydrogenase | - |
| KKZ10_RS08560 (1800377) | 1800377..1801276 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| KKZ10_RS08565 (1801422) | 1801422..1801472 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KKZ10_RS08570 (1801756) | 1801756..1802007 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KKZ10_RS08575 (1802004) | 1802004..1802258 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KKZ10_RS08580 (1802341) | 1802341..1803165 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| KKZ10_RS08585 (1803211) | 1803211..1804140 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| KKZ10_RS08590 (1804355) | 1804355..1804417 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KKZ10_RS08595 (1804407) | 1804407..1805765 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KKZ10_RS08600 (1805944) | 1805944..1807002 | + | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KKZ10_RS08605 (1807016) | 1807016..1807243 | + | 228 | WP_000985272.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T204315 WP_000767829.1 NZ_CP075722:1802004-1802258 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T204315 NZ_CP100696:45736-46041 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGACAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGTCTTACCGCCTGCTGACCACGGATATGGCCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTGCAGGAGAATGACATCAGAAATGCCATTAACCTGATGTTCCGGGGGGTCTGA
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGACAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGTCTTACCGCCTGCTGACCACGGATATGGCCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTGCAGGAGAATGACATCAGAAATGCCATTAACCTGATGTTCCGGGGGGTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT204315 WP_001259255.1 NZ_CP075722:1801756-1802007 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT204315 NZ_CP100696:45516-45734 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGAAGCAGCGCATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAGGGAATACGACGTGAATATCTCCGGCCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGGACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTGACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA
ATGAAGCAGCGCATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAGGGAATACGACGTGAATATCTCCGGCCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGCGCCGGACGCTGGCAGGAAGAAAACCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTGACGGATCGTTTGCTGACGAAAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|