Detailed information of TA system TA204241

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1877047..1877305
• Replicon: chromosome
• Accession: NZ_CP075697
• Organism: Escherichia coli strain STEC2018-607

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JFX52_RS09175
• Protein ID: WP_000809168.1
• Coordinates: 1877153..1877305 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1877047..1877104 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFX52_RS09155	1872074..1873426	+	1353	Protein_1812	fimbria/pilus outer membrane usher protein	-
JFX52_RS09160	1873439..1874398	+	960	WP_000871671.1	hypothetical protein	-
JFX52_RS09165	1874436..1875335	-	900	WP_001300855.1	transcriptional activator NhaR	-
JFX52_RS09170	1875401..1876567	-	1167	WP_000681359.1	Na+/H+ antiporter NhaA	-
-	1877047..1877104	-	58	-	-	Antitoxin
JFX52_RS09175	1877153..1877305	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JFX52_RS09180	1877409..1878539	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
JFX52_RS09185	1878628..1880544	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JFX52_RS09190	1880921..1881325	+	405	WP_000843559.1	DUF2541 family protein	-
JFX52_RS09195	1881351..1882064	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T204241 WP_000809168.1 NZ_CP075697:1877153-1877305 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T204241 NZ_CP100682:317594-317947 [Salmonella enterica subsp. enterica serovar Goldcoast]
ATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGGCATGCCTGATCCTGG
GCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGTGGCTGCTGGCGGCAA
TGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTTATTACGCTGCTGTTT
TTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGCGGCAGGGCGGCTTAC
GCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT204241 NZ_CP075697:c1877104-1877047 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin