Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 485714..486216 | Replicon | chromosome |
| Accession | NZ_CP075665 | ||
| Organism | Escherichia coli strain STEC2018-553 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | JFY30_RS02265 | Protein ID | WP_000767829.1 |
| Coordinates | 485962..486216 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | JFY30_RS02260 | Protein ID | WP_001259255.1 |
| Coordinates | 485714..485965 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFY30_RS02235 (480892) | 480892..481959 | - | 1068 | WP_000080131.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| JFY30_RS02240 (481959) | 481959..483029 | - | 1071 | WP_000108967.1 | histidinol-phosphate transaminase | - |
| JFY30_RS02245 (483026) | 483026..484330 | - | 1305 | WP_001368033.1 | histidinol dehydrogenase | - |
| JFY30_RS02250 (484336) | 484336..485235 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| JFY30_RS02255 (485381) | 485381..485431 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| JFY30_RS02260 (485714) | 485714..485965 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| JFY30_RS02265 (485962) | 485962..486216 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| JFY30_RS02270 (486299) | 486299..487123 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| JFY30_RS02275 (487169) | 487169..488098 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| JFY30_RS02280 (488313) | 488313..488375 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| JFY30_RS02285 (488365) | 488365..489723 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| JFY30_RS02290 (489902) | 489902..490960 | + | 1059 | WP_000492340.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| JFY30_RS02295 (490974) | 490974..491156 | + | 183 | WP_000985269.1 | sulfurtransferase TusA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T204181 WP_000767829.1 NZ_CP075665:485962-486216 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T204181 NZ_CP100660:1070957-1071286 [Pseudomonas fluorescens]
ATGTGCTCGGAATTCGTCGTCGAATTCAGCGAGCTGGAGGAAGTGGTGCAGGATGAGCTGCTGGCGCAGTTGCACTTACT
CAAATGCATCGGGCCTGCGCTGGGAAGGCCGCATGTAGATACGTTGAAGGGCTCTATGTATTCGAACATGAAAGAGTTGC
GATTCAATGCCGCTGGCGGCGTGTGGCGGGTAGCTTTCGCTTTCGACCGCTACCGCTCTGCACTTCTGCTGGCTGCTGGT
AACAAAGCAGGTATCAGTGAACGCAGGTTTTACAGGAGTCTGATCGACCGTGCCGATGAGCGCTTCGATCGGCATTTGTC
CAGAGGTTGA
ATGTGCTCGGAATTCGTCGTCGAATTCAGCGAGCTGGAGGAAGTGGTGCAGGATGAGCTGCTGGCGCAGTTGCACTTACT
CAAATGCATCGGGCCTGCGCTGGGAAGGCCGCATGTAGATACGTTGAAGGGCTCTATGTATTCGAACATGAAAGAGTTGC
GATTCAATGCCGCTGGCGGCGTGTGGCGGGTAGCTTTCGCTTTCGACCGCTACCGCTCTGCACTTCTGCTGGCTGCTGGT
AACAAAGCAGGTATCAGTGAACGCAGGTTTTACAGGAGTCTGATCGACCGTGCCGATGAGCGCTTCGATCGGCATTTGTC
CAGAGGTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT204181 WP_001259255.1 NZ_CP075665:485714-485965 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT204181 NZ_CP100660:1071291-1071620 [Pseudomonas fluorescens]
ATGTACAAGACACTTGATGAGGTTATCAACGAACTTTCGCCTGAGCGCAGGGCGAAAGTCGAAAAGCGTGGGCAAGAGCT
GATTCGTGAGGAAATGACCCTGCAATCGTTACGCAAGCAGCTTCAAATTACTCAAGAGGACTTGGCGAAGCGCCTTGATA
TCCGCCAAGGCAATATCTCCAAAGTCGAGAGTCGTGGGGACATGTTGATATCTACTTTGCGCAGCTACCTCGAAGCCATG
GGTGGCCGCCTGGAACTGGTGGTGCATTTGCCTGGTCGTGCGCCTGTCTCGATTGACGGTATTGCTGAAGATCCAATTTC
ACACGTTTGA
ATGTACAAGACACTTGATGAGGTTATCAACGAACTTTCGCCTGAGCGCAGGGCGAAAGTCGAAAAGCGTGGGCAAGAGCT
GATTCGTGAGGAAATGACCCTGCAATCGTTACGCAAGCAGCTTCAAATTACTCAAGAGGACTTGGCGAAGCGCCTTGATA
TCCGCCAAGGCAATATCTCCAAAGTCGAGAGTCGTGGGGACATGTTGATATCTACTTTGCGCAGCTACCTCGAAGCCATG
GGTGGCCGCCTGGAACTGGTGGTGCATTTGCCTGGTCGTGCGCCTGTCTCGATTGACGGTATTGCTGAAGATCCAATTTC
ACACGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|