Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1625901..1626442 Replicon chromosome
Accession NZ_CP075652
Organism Escherichia coli strain STEC17-183

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag JFX43_RS08155 Protein ID WP_000615976.1
Coordinates 1626164..1626442 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag JFX43_RS08150 Protein ID WP_032331203.1
Coordinates 1625901..1626161 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFX43_RS08125 (1621684) 1621684..1622469 - 786 WP_000207589.1 putative lateral flagellar export/assembly protein LafU -
JFX43_RS08130 (1622441) 1622441..1624153 + 1713 Protein_1602 flagellar biosynthesis protein FlhA -
JFX43_RS08135 (1624258) 1624258..1624536 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
JFX43_RS08140 (1624529) 1624529..1624885 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
JFX43_RS08145 (1624942) 1624942..1625715 - 774 WP_000543896.1 C40 family peptidase -
JFX43_RS08150 (1625901) 1625901..1626161 + 261 WP_032331203.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JFX43_RS08155 (1626164) 1626164..1626442 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JFX43_RS08160 (1626598) 1626598..1627338 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
JFX43_RS08165 (1627309) 1627309..1628076 - 768 WP_000333380.1 class II glutamine amidotransferase -
JFX43_RS08170 (1628282) 1628282..1628860 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T204121 WP_000615976.1 NZ_CP075652:1626164-1626442 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T204121 NZ_CP100544:1974864-1974967 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9421.80 Da        Isoelectric Point: 5.0758

>AT204121 WP_032331203.1 NZ_CP075652:1625901-1626161 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSETGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT204121 NZ_CP100544:c1975005-1974734 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure

References