Detailed information of TA system TA204108

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4265052..4265310
• Replicon: chromosome
• Accession: NZ_CP075649
• Organism: Escherichia coli strain STEC17-190

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JFX56_RS20400
• Protein ID: WP_000809168.1
• Coordinates: 4265158..4265310 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4265052..4265109 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFX56_RS24845	4260099..4261430	+	1332	Protein_4015	fimbria/pilus outer membrane usher protein	-
JFX56_RS20385	4261443..4262402	+	960	WP_000871667.1	hypothetical protein	-
JFX56_RS20390	4262441..4263340	-	900	WP_001300855.1	transcriptional activator NhaR	-
JFX56_RS20395	4263406..4264572	-	1167	WP_000681368.1	Na+/H+ antiporter NhaA	-
-	4265052..4265109	-	58	-	-	Antitoxin
JFX56_RS20400	4265158..4265310	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JFX56_RS20405	4265414..4266544	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
JFX56_RS20410	4266633..4268549	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JFX56_RS20415	4268926..4269330	+	405	WP_000843559.1	DUF2541 family protein	-
JFX56_RS20420	4269356..4270069	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T204108 WP_000809168.1 NZ_CP075649:4265158-4265310 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T204108 NZ_CP100542:c4636042-4635758 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT204108 NZ_CP075649:c4265109-4265052 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin