Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 55287..55551 | Replicon | plasmid pP15-385-b |
| Accession | NZ_CP075629 | ||
| Organism | Escherichia coli strain P15-385 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | JFX93_RS24995 | Protein ID | WP_001331364.1 |
| Coordinates | 55399..55551 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 55287..55344 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX93_RS24980 (50526) | 50526..52817 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| JFX93_RS24985 (52810) | 52810..53880 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| JFX93_RS24990 (53899) | 53899..55107 | - | 1209 | WP_000121274.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (55287) | 55287..55344 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (55287) | 55287..55344 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (55287) | 55287..55344 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (55287) | 55287..55344 | - | 58 | NuclAT_0 | - | Antitoxin |
| JFX93_RS24995 (55399) | 55399..55551 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| JFX93_RS25000 (55623) | 55623..55874 | - | 252 | WP_001291965.1 | hypothetical protein | - |
| JFX93_RS25605 (56375) | 56375..56470 | + | 96 | WP_288144227.1 | DinQ-like type I toxin DqlB | - |
| JFX93_RS25010 (56535) | 56535..56711 | - | 177 | WP_001054904.1 | hypothetical protein | - |
| JFX93_RS25015 (56920) | 56920..57129 | - | 210 | WP_198793044.1 | hemolysin expression modulator Hha | - |
| JFX93_RS25020 (57227) | 57227..57841 | - | 615 | WP_001749187.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| JFX93_RS25025 (57917) | 57917..60085 | - | 2169 | WP_063267537.1 | IncI1-type conjugal transfer membrane protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..100108 | 100108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T204008 WP_001331364.1 NZ_CP075629:55399-55551 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T204008 NZ_CP100501:44827-45102 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCACCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCACCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 58 bp
>AT204008 NZ_CP075629:c55344-55287 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
