Detailed information of TA system TA203978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 43315..43520
• Replicon: plasmid p1207_3
• Accession: NZ_CP075607
• Organism: Enterococcus faecalis strain 1207/14

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: KKP64_RS17300
• Protein ID: WP_002387930.1
• Coordinates: 43315..43416 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	43456..43520 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKP64_RS17255	38431..38793	-	363	WP_000241511.1	type II toxin-antitoxin system PemK/MazF family toxin	-
KKP64_RS17260	38787..39050	-	264	WP_000245205.1	PbsX family transcriptional regulator	-
KKP64_RS17265	39227..39847	+	621	WP_021732893.1	recombinase family protein	-
KKP64_RS17270	39864..40151	+	288	WP_010708491.1	hypothetical protein	-
KKP64_RS17275	40145..40369	+	225	WP_010708492.1	ultraviolet resistance protein UvrA repressor UvrC	-
KKP64_RS17280	40430..40639	+	210	WP_002387638.1	hypothetical protein	-
KKP64_RS17805	40801..40953	+	153	WP_225850000.1	DUF6440 family protein	-
KKP64_RS17290	41380..42708	+	1329	WP_002387639.1	ultraviolet resistance protein UvrA	-
KKP64_RS17295	42705..43055	+	351	WP_002365943.1	hypothetical protein	-
KKP64_RS17810	43012..43224	+	213	WP_002365945.1	hypothetical protein	-
KKP64_RS17300	43315..43416	+	102	WP_002387930.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	43456..43520	-	65	-	-	Antitoxin
-	43456..43558	-	103	NuclAT_0	-	-
-	43456..43558	-	103	NuclAT_0	-	-
-	43456..43558	-	103	NuclAT_0	-	-
-	43456..43558	-	103	NuclAT_0	-	-
KKP64_RS17305	43755..44216	+	462	WP_002365946.1	hypothetical protein	-
KKP64_RS17310	44387..44677	+	291	WP_002365947.1	hypothetical protein	-
KKP64_RS17315	44781..45152	-	372	WP_000049959.1	replication-associated protein RepC	-
KKP64_RS17320	45145..45990	-	846	WP_000239313.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..46461	46461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3731.42 Da
• Isoelectric Point: 4.1672

>T203978 WP_002387930.1 NZ_CP075607:43315-43416 [Enterococcus faecalis]
VKDLMSLVIAPIFVGLVLEMISRVLDEEDDSRK

Nucleotide

• Length: 102 bp

>T203978 NZ_CP100500:c49995-49621 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCAACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Nucleotide

• Length: 65 bp

>AT203978 NZ_CP075607:c43520-43456 [Enterococcus faecalis]
AACGACATTAAATCGTACAGATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Structures

Antitoxin