Detailed information of TA system TA203969

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 3148138..3148579
• Replicon: chromosome
• Accession: NZ_CP075604
• Organism: Enterococcus faecalis strain 1207/14

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: KKP64_RS15700
• Protein ID: WP_002396786.1
• Coordinates: 3148436..3148579 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3148138..3148339 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKP64_RS15675	3143713..3145008	-	1296	WP_002396787.1	ATP-binding protein	-
KKP64_RS15680	3145470..3147086	+	1617	WP_002358967.1	phosphatase PAP2/LCP family protein	-
KKP64_RS15685	3147441..3147563	+	123	WP_002404776.1	putative holin-like toxin	-
KKP64_RS15690	3147749..3147946	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	-
KKP64_RS15695	3148065..3148205	+	141	WP_077143780.1	putative holin-like toxin	-
-	3148138..3148339	-	202	-	-	Antitoxin
KKP64_RS15700	3148436..3148579	+	144	WP_002396786.1	putative holin-like toxin	Toxin
KKP64_RS15705	3148774..3153049	-	4276	Protein_3093	WxL domain-containing protein	-
KKP64_RS15710	3153185..3153463	-	279	WP_216788112.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T203969 WP_002396786.1 NZ_CP075604:3148436-3148579 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T203969 NZ_CP100497:663793-664167 [Klebsiella michiganensis]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTATGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTGGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT203969 NZ_CP075604:c3148339-3148138 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin