20396

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2491305..2491489 Replicon chromosome
Accession NC_002745
Organism Staphylococcus aureus subsp. aureus N315

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SA_RS12740 Protein ID WP_000482652.1
Coordinates 2491382..2491489 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2491305..2491365 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA_RS12715 2486760..2486927 - 168 Protein_2383 hypothetical protein -
SA_RS12725 (SA2216) 2487158..2488891 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
SA_RS12730 (SA2217) 2488916..2490679 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2491305..2491365 + 61 - - Antitoxin
SA_RS12740 2491382..2491489 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SA_RS12745 (SA2219) 2491623..2492009 - 387 WP_000779360.1 flippase GtxA -
SA_RS12750 (SA2220) 2492277..2493419 + 1143 WP_001176863.1 glycerate kinase -
SA_RS12755 (SA2221) 2493479..2494138 + 660 WP_000831298.1 membrane protein -
SA_RS12760 (SA2222) 2494320..2495531 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SA_RS12765 (SA2223) 2495654..2496127 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T20396 WP_000482652.1 NC_002745:c2491489-2491382 [Staphylococcus aureus subsp. aureus N315]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T20396 NC_002745:c2491489-2491382 [Staphylococcus aureus subsp. aureus N315]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT20396 NC_002745:2491305-2491365 [Staphylococcus aureus subsp. aureus N315]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References