Detailed information of TA system TA203958

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 3147749..3148063
• Replicon: chromosome
• Accession: NZ_CP075604
• Organism: Enterococcus faecalis strain 1207/14

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: C7CYQ7
• Locus tag: KKP64_RS15690
• Protein ID: WP_002358966.1
• Coordinates: 3147749..3147946 (+)
• Length: 66 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3147879..3148063 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKP64_RS15670	3143072..3143704	-	633	WP_002358972.1	RloB family protein	-
KKP64_RS15675	3143713..3145008	-	1296	WP_002396787.1	ATP-binding protein	-
KKP64_RS15680	3145470..3147086	+	1617	WP_002358967.1	phosphatase PAP2/LCP family protein	-
KKP64_RS15685	3147441..3147563	+	123	WP_002404776.1	putative holin-like toxin	-
KKP64_RS15690	3147749..3147946	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	3147879..3148063	-	185	-	-	Antitoxin
KKP64_RS15695	3148065..3148205	+	141	WP_077143780.1	putative holin-like toxin	-
KKP64_RS15700	3148436..3148579	+	144	WP_002396786.1	putative holin-like toxin	-
KKP64_RS15705	3148774..3153049	-	4276	Protein_3093	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (32-65)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7571.21 Da
• Isoelectric Point: 10.8134

>T203958 WP_002358966.1 NZ_CP075604:3147749-3147946 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 198 bp

>T203958 NZ_CP100488:42188-42340 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT203958 NZ_CP075604:c3148063-3147879 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: C7CYQ7

Antitoxin