Detailed information of TA system TA203953

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 3147441..3147692
• Replicon: chromosome
• Accession: NZ_CP075604
• Organism: Enterococcus faecalis strain 1207/14

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BWW4
• Locus tag: KKP64_RS15685
• Protein ID: WP_002404776.1
• Coordinates: 3147441..3147563 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	3147629..3147692 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKP64_RS15670	3143072..3143704	-	633	WP_002358972.1	RloB family protein	-
KKP64_RS15675	3143713..3145008	-	1296	WP_002396787.1	ATP-binding protein	-
KKP64_RS15680	3145470..3147086	+	1617	WP_002358967.1	phosphatase PAP2/LCP family protein	-
KKP64_RS15685	3147441..3147563	+	123	WP_002404776.1	putative holin-like toxin	Toxin
-	3147629..3147692	-	64	-	-	Antitoxin
KKP64_RS15690	3147749..3147946	+	198	WP_002358966.1	type I toxin-antitoxin system toxin PepG1	-
KKP64_RS15695	3148065..3148205	+	141	WP_077143780.1	putative holin-like toxin	-
KKP64_RS15700	3148436..3148579	+	144	WP_002396786.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (7-40)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4396.44 Da
• Isoelectric Point: 10.2826

>T203953 WP_002404776.1 NZ_CP075604:3147441-3147563 [Enterococcus faecalis]
MKGVGLLSAYETIQTILGFGMFTIALIALIVKLLKEDKKK

Nucleotide

• Length: 123 bp

>T203953 NZ_CP100486:4527716-4528093 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCGCGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCGGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 64 bp

>AT203953 NZ_CP075604:c3147692-3147629 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTT

Structures

Toxin

• AlphaFold DB: S4BWW4

Antitoxin