Detailed information of TA system TA203946

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 3069999..3070259
• Replicon: chromosome
• Accession: NZ_CP075604
• Organism: Enterococcus faecalis strain 1207/14

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KKP64_RS15330
• Protein ID: WP_156194032.1
• Coordinates: 3070116..3070259 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	3069999..3070183 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKP64_RS15315	3065560..3066273	-	714	WP_002354877.1	trehalose operon repressor	-
KKP64_RS15320	3066535..3069279	+	2745	WP_002404790.1	glycosyl hydrolase family 65 protein	-
KKP64_RS15325	3069294..3069944	+	651	WP_002359015.1	beta-phosphoglucomutase	-
-	3069999..3070183	+	185	-	-	Antitoxin
KKP64_RS15330	3070116..3070259	-	144	WP_156194032.1	type I toxin-antitoxin system toxin PepG1	Toxin
KKP64_RS15335	3070490..3071461	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
KKP64_RS15340	3071636..3072073	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
KKP64_RS15345	3072206..3072760	-	555	WP_002359011.1	Maf family protein	-
KKP64_RS15350	3072785..3074917	-	2133	WP_002359010.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5327.50 Da
• Isoelectric Point: 10.8331

>T203946 WP_156194032.1 NZ_CP075604:c3070259-3070116 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTISLIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T203946 NZ_CP100486:3052746-3053240 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Nucleotide

• Length: 185 bp

>AT203946 NZ_CP075604:3069999-3070183 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGAAATGGTAAACATACCAA

Structures

Antitoxin