Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 694746..694978 Replicon chromosome
Accession NZ_CP075604
Organism Enterococcus faecalis strain 1207/14

Toxin (Protein)


Gene name txpA Uniprot ID Q837V5
Locus tag KKP64_RS03395 Protein ID WP_002366178.1
Coordinates 694746..694862 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 694773..694978 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKP64_RS03385 690184..692442 + 2259 WP_002363179.1 DNA helicase PcrA -
KKP64_RS03390 692568..694598 + 2031 WP_002361258.1 NAD-dependent DNA ligase LigA -
KKP64_RS03395 694746..694862 + 117 WP_002366178.1 putative holin-like toxin Toxin
- 694773..694978 - 206 - - Antitoxin
KKP64_RS03400 695180..695485 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
KKP64_RS03405 695485..696954 + 1470 WP_002361259.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
KKP64_RS03410 696954..698384 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
KKP64_RS03415 698403..699491 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4108.01 Da        Isoelectric Point: 5.9482

>T203942 WP_002366178.1 NZ_CP075604:694746-694862 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Download         Length: 117 bp

>T203942 NZ_CP100486:2586332-2586508 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 206 bp

>AT203942 NZ_CP075604:c694978-694773 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G1S9M0

Antitoxin

Download structure file

References