Detailed information of TA system TA203897

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1236979..1237317
• Replicon: chromosome
• Accession: NZ_CP075563
• Organism: Staphylococcus aureus strain Sta2021027

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KJP35_RS06080
• Protein ID: WP_011447039.1
• Coordinates: 1236979..1237155 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1237143..1237317 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJP35_RS06060	1234809..1234961	+	153	WP_001000058.1	hypothetical protein	-
KJP35_RS06065	1235007..1235294	+	288	WP_001262621.1	hypothetical protein	-
KJP35_RS06070	1235350..1235724	+	375	WP_000340977.1	hypothetical protein	-
KJP35_RS06075	1236097..1236870	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KJP35_RS06080	1236979..1237155	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1237143..1237317	-	175	-	-	Antitoxin
KJP35_RS06090	1237367..1237621	+	255	WP_000611512.1	phage holin	-
KJP35_RS06095	1237633..1238388	+	756	WP_000861038.1	CHAP domain-containing protein	-
KJP35_RS06100	1238579..1239070	+	492	WP_000920038.1	staphylokinase	-
KJP35_RS06105	1239720..1240055	+	336	Protein_1199	SH3 domain-containing protein	-
KJP35_RS06110	1240566..1240916	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KJP35_RS06115	1240969..1241229	-	261	WP_001791826.1	hypothetical protein	-
KJP35_RS06120	1241540..1241719	-	180	WP_000669791.1	hypothetical protein	-
KJP35_RS06125	1242091..1242288	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sea / sak / scn	1192200..1240916	48716

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T203897 WP_011447039.1 NZ_CP075563:1236979-1237155 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T203897 NZ_CP100475:c5653660-5653367 [Mesorhizobium sp. C372A]
ATGACCCTCAGAACCACACCATTCGACGCCGCCGAATATCTTGATGATGCTGAGTCTCAAGCCGAACTGCTCGCTGATGC
GTTCGAGACCGGGGACGCGACTTATATTGCGCACGCCCTCGGCATTGTCGCGCGCGCCCGCGGCATGACAAGCATAGCGA
AGGACGCCGGCGTGACCCGAGAGGCACTCTACAAGGCGCTGAGCGAAAAGGGCGATCCGCGCCTCAGTACATTGCTGGGC
GTAACCAAGGCGCTTGGCCTGCAATTGTCCGCAAAGCCAGTTAATCCCGTTTAG

Antitoxin

Nucleotide

• Length: 175 bp

>AT203897 NZ_CP075563:c1237317-1237143 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin