Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 1212109..1212523 | Replicon | chromosome |
| Accession | NZ_CP075563 | ||
| Organism | Staphylococcus aureus strain Sta2021027 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | KJP35_RS05910 | Protein ID | WP_025174939.1 |
| Coordinates | 1212109..1212360 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KJP35_RS05915 | Protein ID | WP_000028424.1 |
| Coordinates | 1212350..1212523 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KJP35_RS05870 (1207815) | 1207815..1208735 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| KJP35_RS05875 (1208816) | 1208816..1209433 | + | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
| KJP35_RS05880 (1209434) | 1209434..1209904 | + | 471 | WP_000934760.1 | single-stranded DNA-binding protein | - |
| KJP35_RS05885 (1209934) | 1209934..1210827 | + | 894 | WP_000148335.1 | DnaD domain-containing protein | - |
| KJP35_RS05890 (1210834) | 1210834..1211052 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| KJP35_RS05895 (1211061) | 1211061..1211465 | + | 405 | WP_000401978.1 | RusA family crossover junction endodeoxyribonuclease | - |
| KJP35_RS05900 (1211478) | 1211478..1211848 | + | 371 | Protein_1158 | hypothetical protein | - |
| KJP35_RS05905 (1211852) | 1211852..1212094 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| KJP35_RS05910 (1212109) | 1212109..1212360 | + | 252 | WP_025174939.1 | DUF1024 family protein | Toxin |
| KJP35_RS05915 (1212350) | 1212350..1212523 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| KJP35_RS05920 (1212524) | 1212524..1212805 | + | 282 | WP_000454994.1 | hypothetical protein | - |
| KJP35_RS05925 (1212806) | 1212806..1212967 | + | 162 | WP_000889683.1 | hypothetical protein | - |
| KJP35_RS05930 (1212982) | 1212982..1213515 | + | 534 | WP_025920701.1 | dUTP diphosphatase | - |
| KJP35_RS05935 (1213552) | 1213552..1213758 | + | 207 | WP_000195826.1 | DUF1381 domain-containing protein | - |
| KJP35_RS05940 (1213755) | 1213755..1213946 | + | 192 | Protein_1166 | hypothetical protein | - |
| KJP35_RS05945 (1213947) | 1213947..1214150 | + | 204 | WP_001072793.1 | hypothetical protein | - |
| KJP35_RS05950 (1214143) | 1214143..1214268 | + | 126 | WP_031783376.1 | transcriptional regulator | - |
| KJP35_RS05955 (1214268) | 1214268..1214468 | + | 201 | WP_001570807.1 | DUF1514 family protein | - |
| KJP35_RS05960 (1214491) | 1214491..1214961 | + | 471 | WP_000282755.1 | hypothetical protein | - |
| KJP35_RS05965 (1215076) | 1215076..1215528 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| KJP35_RS05970 (1215544) | 1215544..1215888 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
| KJP35_RS05975 (1216017) | 1216017..1216484 | + | 468 | WP_000919026.1 | phage terminase small subunit P27 family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | hlb / sea / sak / scn | 1192200..1240916 | 48716 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9361.22 Da Isoelectric Point: 3.8464
>T203896 WP_025174939.1 NZ_CP075563:1212109-1212360 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T203896 NZ_CP100475:4795228-4795428 [Mesorhizobium sp. C372A]
ATGCCGCCTCGGCTTACAGTCCGCGAAGTCATTCGCCTGCTGGAGACCGACGGTTGGTATCTGGTTGCAACCAAGGGCAG
CCATCGCCAATATAAGCACAAAACCAAAGCCGGCCGCGTCACCGTGGCCGGCAAACCGTCTGAAGAGGTTGCGCCAGGAA
CACTGAACAGCATCCTCAAGCAGTCCGGTTTGAAGGAGTGA
ATGCCGCCTCGGCTTACAGTCCGCGAAGTCATTCGCCTGCTGGAGACCGACGGTTGGTATCTGGTTGCAACCAAGGGCAG
CCATCGCCAATATAAGCACAAAACCAAAGCCGGCCGCGTCACCGTGGCCGGCAAACCGTCTGAAGAGGTTGCGCCAGGAA
CACTGAACAGCATCCTCAAGCAGTCCGGTTTGAAGGAGTGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT203896 WP_000028424.1 NZ_CP075563:1212350-1212523 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT203896 NZ_CP100475:4795433-4795639 [Mesorhizobium sp. C372A]
ATGCGTTACGCGGTGGTGATTGAAAAAGCAGGCAACAATTTCTCTGCCTATGTGCCGGACCTACCCGGCTGCATCGCAAC
TGGTGCTACCGTGCCAGAAGTAGAAATCGAAATTCGCGACGCTATACGCTTTCACATCGAGGGCTTGCGCGCCGATGGGC
TGGAGGTGCCCAAAGGAATCAGTCTCGCTGAATATGTAGAGGCATAA
ATGCGTTACGCGGTGGTGATTGAAAAAGCAGGCAACAATTTCTCTGCCTATGTGCCGGACCTACCCGGCTGCATCGCAAC
TGGTGCTACCGTGCCAGAAGTAGAAATCGAAATTCGCGACGCTATACGCTTTCACATCGAGGGCTTGCGCGCCGATGGGC
TGGAGGTGCCCAAAGGAATCAGTCTCGCTGAATATGTAGAGGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|