Detailed information of TA system TA203891

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1063318..1063596
• Replicon: chromosome
• Accession: NZ_CP075563
• Organism: Staphylococcus aureus strain Sta2021027

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KJP35_RS05100
• Protein ID: WP_001802298.1
• Coordinates: 1063318..1063422 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1063418..1063596 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJP35_RS05085	1060115..1060897	+	783	WP_045177727.1	ABC transporter ATP-binding protein	-
KJP35_RS05090	1060964..1061821	+	858	WP_045177730.1	HAD family hydrolase	-
KJP35_RS05095	1062480..1062638	-	159	WP_001792784.1	hypothetical protein	-
KJP35_RS05100	1063318..1063422	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1063418..1063596	-	179	-	-	Antitoxin
KJP35_RS05110	1063921..1065012	-	1092	WP_045177732.1	lytic regulatory protein	-
KJP35_RS05115	1065278..1066258	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KJP35_RS05120	1066260..1066580	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KJP35_RS05125	1066732..1067397	+	666	WP_045177733.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T203891 WP_001802298.1 NZ_CP075563:1063318-1063422 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T203891 NZ_CP100472:5719072-5719488 [Mesorhizobium sp. C399B]
ATGATCCTCCTCGATACCAATGTCGTTTCGGAGGCCATGAAGCCCGAACCGCATCAAGCTGTGTTGGCCTGGCTTGATAA
CCAGGCCGAGGAAACGCTTTACCTCTCCAGTGTGACGCTCGCCGAAGTGCTGTTCGGCATCGAGGCCATGCCGGCGGGTC
GTCGCAAGGCTGCGCTCGCTGAAACCTTCGCCGGTGTGTGCGCCGTGTTTGAGCGGCGCATCCTGCCTTTCGATACCGAG
GCGGCCCGGCACTATGCCCGACTTGCAGTGAAGGCGAGGGCAGCCGGCAAGGGGTTTCCTGTGCCCGACGGCTACATCGC
GGCAATCGCCTCCGCAAACGGCTTTCATCTCGCCTCGCGTGACACGGCGCCATTCCATGCGGCCGGCGTGCCTGTCATCG
ATCCTTGGCAGCCGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT203891 NZ_CP075563:c1063596-1063418 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin