Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 805686..806203 | Replicon | chromosome |
| Accession | NZ_CP075563 | ||
| Organism | Staphylococcus aureus strain Sta2021027 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KJP35_RS03750 | Protein ID | WP_000113262.1 |
| Coordinates | 805937..806203 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KJP35_RS03745 | Protein ID | WP_000584499.1 |
| Coordinates | 805686..805937 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KJP35_RS03715 (801384) | 801384..802103 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| KJP35_RS03720 (802100) | 802100..802831 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KJP35_RS03725 (802928) | 802928..804178 | - | 1251 | WP_001012241.1 | FemA/FemB family glycyltransferase FmhA | - |
| KJP35_RS03730 (804433) | 804433..804795 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KJP35_RS03735 (804814) | 804814..805413 | + | 600 | WP_000162812.1 | DsbA family protein | - |
| KJP35_RS03740 (805420) | 805420..805521 | + | 102 | WP_001791744.1 | hypothetical protein | - |
| KJP35_RS03745 (805686) | 805686..805937 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KJP35_RS03750 (805937) | 805937..806203 | + | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KJP35_RS03755 (806238) | 806238..806309 | + | 72 | WP_223200558.1 | hypothetical protein | - |
| KJP35_RS03760 (806497) | 806497..808047 | + | 1551 | WP_045177665.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KJP35_RS03765 (808233) | 808233..808700 | + | 468 | WP_000153346.1 | SRPBCC domain-containing protein | - |
| KJP35_RS03770 (808784) | 808784..808966 | + | 183 | WP_000230294.1 | hypothetical protein | - |
| KJP35_RS03775 (809183) | 809183..810007 | + | 825 | WP_255777486.1 | formate/nitrite transporter family protein | - |
| KJP35_RS03780 (810240) | 810240..810776 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T203889 WP_000113262.1 NZ_CP075563:805937-806203 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T203889 NZ_CP100472:2886584-2886838 [Mesorhizobium sp. C399B]
ATGAACTGGCATCTGCAGGACGCAAAAAACAATCTCTCGAAGCTGGTTCAGCAGGCTCGTGAAAAGGGCCCGCAGACCAT
CACCTTGCGTGGAAAGCCCGCTGCTGTCGTGTTGGCCGCTGAAGAATACGAAAGGCTCGTCGGTTCTAAGCCCTCACTTG
CGGAATACCTTCTTTCCGGTCCCGAGTGGGACGACGACTTCGTCGAAGAGGTCAATCGCCGCTCCAAGGGGCCCGGCAGA
GACGTGGACCTCTGA
ATGAACTGGCATCTGCAGGACGCAAAAAACAATCTCTCGAAGCTGGTTCAGCAGGCTCGTGAAAAGGGCCCGCAGACCAT
CACCTTGCGTGGAAAGCCCGCTGCTGTCGTGTTGGCCGCTGAAGAATACGAAAGGCTCGTCGGTTCTAAGCCCTCACTTG
CGGAATACCTTCTTTCCGGTCCCGAGTGGGACGACGACTTCGTCGAAGAGGTCAATCGCCGCTCCAAGGGGCCCGGCAGA
GACGTGGACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT203889 WP_000584499.1 NZ_CP075563:805686-805937 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT203889 NZ_CP100472:2886838-2887239 [Mesorhizobium sp. C399B]
ATGTTTCTTCTGGACACGAACGTCGTGTCGGGTGCGCGAAAGCGAGAGGGGCCAGTGGCGGATTGGATAATCAAGCAAGA
GCGCCAGTCTCTGTTTCTAAGCGTCATCACGCTCGGTGAAATCGCACGCGGAATCGAAATGAAGCGGCGAAACGACCCCG
ACACTGCAAACCATTTAGCAGCGTGGTTCCACGGTCTGCGCCACAGCTACGAAAACCGAATTCTCGGCATAGACGAGAGC
ATCGCTGCCCAATGGGGTCGCATCTCCGCGATCCGCACGCGCGGCGACGCAGATGGGCTTATAGCCGCGACGGCGCTCTT
CCACGACCTCATACTGGTCACACGCAACGTCGCCGATTTCGACGATACTGGCGTCACAATGTTCAACCCTTGGGAAGCCT
GA
ATGTTTCTTCTGGACACGAACGTCGTGTCGGGTGCGCGAAAGCGAGAGGGGCCAGTGGCGGATTGGATAATCAAGCAAGA
GCGCCAGTCTCTGTTTCTAAGCGTCATCACGCTCGGTGAAATCGCACGCGGAATCGAAATGAAGCGGCGAAACGACCCCG
ACACTGCAAACCATTTAGCAGCGTGGTTCCACGGTCTGCGCCACAGCTACGAAAACCGAATTCTCGGCATAGACGAGAGC
ATCGCTGCCCAATGGGGTCGCATCTCCGCGATCCGCACGCGCGGCGACGCAGATGGGCTTATAGCCGCGACGGCGCTCTT
CCACGACCTCATACTGGTCACACGCAACGTCGCCGATTTCGACGATACTGGCGTCACAATGTTCAACCCTTGGGAAGCCT
GA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|