Detailed information of TA system TA203887

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 780678..780862
• Replicon: chromosome
• Accession: NZ_CP075563
• Organism: Staphylococcus aureus strain Sta2021027

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KJP35_RS03615
• Protein ID: WP_000482647.1
• Coordinates: 780678..780785 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	780802..780862 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJP35_RS03590	776040..776513	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
KJP35_RS03595	776636..777847	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KJP35_RS03600	778029..778688	-	660	WP_000831298.1	membrane protein	-
KJP35_RS03605	778748..779890	-	1143	WP_001176863.1	glycerate kinase	-
KJP35_RS03610	780158..780544	+	387	WP_000779360.1	flippase GtxA	-
KJP35_RS03615	780678..780785	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	780802..780862	-	61	-	-	Antitoxin
KJP35_RS03620	781492..783255	+	1764	WP_006191000.1	ABC transporter ATP-binding protein	-
KJP35_RS03625	783280..785013	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
KJP35_RS03630	785244..785411	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-131)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T203887 WP_000482647.1 NZ_CP075563:780678-780785 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T203887 NZ_CP100472:c1080322-1079885 [Mesorhizobium sp. C399B]
GTGACCTTCCTGCTCGACGTCAATGTGTTGATTGCGTTGATCGATCCGGCTCACGTCGCGCATGAAGATGCCCATCGGTG
GTTCCAATCCTCCGGGCATTTATCATGGGCAACATGTCCCATTACCGAGAATGGCGTCATCAGGATTGTAAGCAACCCGA
AATACCCCAATTCTCCGGGTTCGCCCGCCGTGGTGGCGCAGGTTGTCGGCAAGCTGCATGCCCTTTCAGGACATCAGTTC
TGGCCTGACGAGATCAGCCTTGTCGGTTCCAACGACATCGATGCAGCCAGGATCCTCACCCCGGCACAGGTAACGGATAG
CTATCTGTTGGGACTCGCCAAGGCGCGTGACGGCCAATTGGCGACGTTTGACCGAAAGCTGTCGACGGCAGCGGTAAAGG
GAGGGAGGTCGATCCTCCACCTGATCCCAAGCGAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT203887 NZ_CP075563:c780862-780802 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin