Detailed information of TA system TA203886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 749139..749662
• Replicon: chromosome
• Accession: NZ_CP075563
• Organism: Staphylococcus aureus strain Sta2021027

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KJP35_RS03475
• Protein ID: WP_045177693.1
• Coordinates: 749396..749662 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: KJP35_RS03470
• Protein ID: WP_000587618.1
• Coordinates: 749139..749396 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJP35_RS03455 (745635)	745635..746384	-	750	WP_000072443.1	CPBP family lipoprotein N-acylation protein LnsB	-
KJP35_RS03460 (746579)	746579..748156	+	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
KJP35_RS03465 (748324)	748324..748779	-	456	WP_000732090.1	YehR family lipoprotein	-
KJP35_RS03470 (749139)	749139..749396	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KJP35_RS03475 (749396)	749396..749662	+	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
KJP35_RS03480 (750018)	750018..751094	+	1077	WP_001076673.1	M42 family metallopeptidase	-
KJP35_RS03485 (751342)	751342..752004	+	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
KJP35_RS03490 (751997)	751997..752773	+	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
KJP35_RS03495 (753169)	753169..754356	+	1188	WP_045177690.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T203886 WP_045177693.1 NZ_CP075563:749396-749662 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T203886 NZ_CP100443:5537138-5537485 [Streptomyces rimosus subsp. rimosus]
ATGCGGCGCGGTGACCTCTATCTGGTTGATCTGGAGCCGGTCCGGGGGAGCGAGGCCAACAAGTACCGTCCTGCGGTGGT
CGTGTCCAACGACGCGGCCAATCGGTCCGTGCAGCGCGCCGGAAGGGGTGTGGTGACGGTCGTGCCTGTGACGGCCAACG
TCGCCCGGGTCTACCCGTTCCAGGTGCTGCTGACCGCCGACGACTGCGGGCTGCCGCGCGACTCGAAGGCCCAGTGCGAG
CAGGTGCGCGCGGTGTCCGTCGAGCGGCTGGGGCGGCGGGTCGGCAGCGTCCCGGCGCGCGTGATGGTTGGGCTGGACGC
GGCCCTGCGCAGGCATCTGGCGCTCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT203886 WP_000587618.1 NZ_CP075563:749139-749396 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT203886 NZ_CP100443:5536915-5537151 [Streptomyces rimosus subsp. rimosus]
ATGAAGATCAGCGTCAGCCTGCCGGAAGAGGACATCGCCTTCCTCGACGCGTACGGCAAGAAGACGGACGCCGATTCGCG
GTCGGCGGTGATCCACGCGGCGGTCGAGCTGCTGCGTGCCTCCGAGCTGGAGGCGGATTACGCCTCGGCGTGGGAGGAGT
GGGACGAGAGCGACGACGCGCTGCTGTGGGACGGGGTCTCCGGGGACGGGATCGGAAGCGCCGATGCGGCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: T1YBB2