203885

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2031594..2032117 Replicon chromosome
Accession NZ_CP075562
Organism Staphylococcus aureus strain Sta2021010

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag KI818_RS10405 Protein ID WP_000074045.1
Coordinates 2031594..2031860 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag KI818_RS10410 Protein ID WP_000587619.1
Coordinates 2031860..2032117 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI818_RS10385 (2026901) 2026901..2028088 - 1188 WP_000026194.1 MFS transporter -
KI818_RS10390 (2028484) 2028484..2029260 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KI818_RS10395 (2029253) 2029253..2029915 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
KI818_RS10400 (2030163) 2030163..2031239 - 1077 WP_001076671.1 M42 family metallopeptidase -
KI818_RS10405 (2031594) 2031594..2031860 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
KI818_RS10410 (2031860) 2031860..2032117 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KI818_RS10415 (2032477) 2032477..2032932 + 456 WP_000732079.1 DUF1307 domain-containing protein -
KI818_RS10420 (2033100) 2033100..2034677 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
KI818_RS10425 (2034873) 2034873..2035622 + 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
KI818_RS10430 (2035846) 2035846..2037039 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T203885 WP_000074045.1 NZ_CP075562:c2031860-2031594 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T203885 NZ_CP100443:2867326-2867589 [Streptomyces rimosus subsp. rimosus]
GTGAGTGAGTACCGCACCGTCTTCCGCCCCGAGGCTCAGACCGAACTCCGCAAGGTCCCGCGAGACATGGCTCTCCGCAT
TCTGGCGAAGCTGACCGAGTTGGAGACCGACCCGCTGGGGTTCAACACCACCGCCCTCGTCTCCCAGCCCGACCGCCGAC
GCCTACGAGTGGGTGACTACCGCCTGATCTACACGATCGACAACGGCGAGCTGGTGGTGTGGGTGGTACACGTCGGGCAT
CGCTCCACCGTCTACGACGCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT203885 WP_000587619.1 NZ_CP075562:c2032117-2031860 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT203885 NZ_CP100443:2867064-2867333 [Streptomyces rimosus subsp. rimosus]
ATGACGCAGCCACTGCCCATAGAGTCCATCCGCGATGTCCGGGCGCATCTGGCCGAGGTCGTTGAGCGAGCCGACCGGGA
CGACGTACCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGACGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGATGAGCGCATGGCCAACCCTGCACCCGGCATCCCGCTCGAGGACATC
ATGAGGGAGACGCTGGCACGCAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References