Detailed information of TA system TA203883

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2000092..2000276
• Replicon: chromosome
• Accession: NZ_CP075562
• Organism: Staphylococcus aureus strain Sta2021010

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KI818_RS10265
• Protein ID: WP_000482652.1
• Coordinates: 2000169..2000276 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2000092..2000152 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI818_RS10250	1995547..1995714	-	168	WP_001789205.1	hypothetical protein	-
KI818_RS10255	1995945..1997678	-	1734	WP_173950615.1	ABC transporter ATP-binding protein	-
KI818_RS10260	1997703..1999466	-	1764	WP_001064837.1	ABC transporter ATP-binding protein	-
-	2000092..2000152	+	61	-	-	Antitoxin
KI818_RS10265	2000169..2000276	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
KI818_RS10270	2000410..2000796	-	387	WP_000779357.1	flippase GtxA	-
KI818_RS10275	2001064..2002206	+	1143	WP_001176863.1	glycerate kinase	-
KI818_RS10280	2002266..2002925	+	660	WP_234494543.1	hypothetical protein	-
KI818_RS10285	2003107..2004318	+	1212	WP_001191922.1	multidrug effflux MFS transporter	-
KI818_RS10290	2004441..2004914	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T203883 WP_000482652.1 NZ_CP075562:c2000276-2000169 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T203883 NZ_CP100436:c1317314-1316568 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGTGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGACGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT203883 NZ_CP075562:2000092-2000152 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin