Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1974785..1975302 | Replicon | chromosome |
| Accession | NZ_CP075562 | ||
| Organism | Staphylococcus aureus strain Sta2021010 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KI818_RS10130 | Protein ID | WP_000113262.1 |
| Coordinates | 1974785..1975051 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KI818_RS10135 | Protein ID | WP_000584499.1 |
| Coordinates | 1975051..1975302 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI818_RS10100 (1970205) | 1970205..1970741 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KI818_RS10105 (1970975) | 1970975..1971799 | - | 825 | WP_000594629.1 | formate/nitrite transporter family protein | - |
| KI818_RS10110 (1972015) | 1972015..1972200 | - | 186 | WP_000230293.1 | hypothetical protein | - |
| KI818_RS10115 (1972284) | 1972284..1972751 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| KI818_RS10120 (1972937) | 1972937..1974490 | - | 1554 | WP_000727769.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KI818_RS10125 (1974679) | 1974679..1974750 | - | 72 | Protein_1961 | hypothetical protein | - |
| KI818_RS10130 (1974785) | 1974785..1975051 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KI818_RS10135 (1975051) | 1975051..1975302 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KI818_RS10140 (1975467) | 1975467..1975547 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| KI818_RS10145 (1975575) | 1975575..1976174 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| KI818_RS10150 (1976193) | 1976193..1976555 | - | 363 | WP_000819840.1 | DUF4467 domain-containing protein | - |
| KI818_RS10155 (1976810) | 1976810..1978060 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| KI818_RS10160 (1978157) | 1978157..1978888 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KI818_RS10165 (1978885) | 1978885..1979604 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T203882 WP_000113262.1 NZ_CP075562:c1975051-1974785 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T203882 NZ_CP100436:510123-510473 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT203882 WP_000584499.1 NZ_CP075562:c1975302-1975051 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT203882 NZ_CP100436:509837-510118 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|