Detailed information of TA system TA203881

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1715068..1715285
• Replicon: chromosome
• Accession: NZ_CP075562
• Organism: Staphylococcus aureus strain Sta2021010

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KI818_RS08780
• Protein ID: WP_001802298.1
• Coordinates: 1715181..1715285 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1715068..1715123 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI818_RS08755	1711262..1711927	-	666	WP_001024095.1	SDR family oxidoreductase	-
KI818_RS08760	1712079..1712399	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KI818_RS08765	1712401..1713381	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KI818_RS08770	1713647..1714738	+	1092	WP_000495683.1	hypothetical protein	-
-	1715068..1715123	+	56	-	-	Antitoxin
KI818_RS08780	1715181..1715285	-	105	WP_001802298.1	hypothetical protein	Toxin
KI818_RS08785	1715446..1715929	-	484	Protein_1702	recombinase family protein	-
KI818_RS08790	1715972..1717108	-	1137	WP_000115564.1	SAP domain-containing protein	-
KI818_RS08795	1717397..1717489	+	93	WP_001790138.1	hypothetical protein	-
KI818_RS08800	1717778..1717962	+	185	Protein_1705	exotoxin	-
KI818_RS08805	1718194..1719051	-	858	WP_000370924.1	HAD family hydrolase	-
KI818_RS08810	1719119..1719901	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-95)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T203881 WP_001802298.1 NZ_CP075562:c1715285-1715181 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T203881 NZ_CP100432:c2073068-2072739 [Streptococcus suis T15]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT203881 NZ_CP075562:1715068-1715123 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin