Detailed information of TA system TA203876

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1541860..1542167
• Replicon: chromosome
• Accession: NZ_CP075562
• Organism: Staphylococcus aureus strain Sta2021010

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KI818_RS07820
• Protein ID: WP_011447039.1
• Coordinates: 1541991..1542167 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1541860..1541999 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI818_RS07780 (1537201)	1537201..1537461	+	261	WP_001791826.1	hypothetical protein	-
KI818_RS07785 (1537514)	1537514..1537864	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KI818_RS07790 (1538546)	1538546..1538995	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
KI818_RS07795 (1539090)	1539090..1539425	-	336	Protein_1509	SH3 domain-containing protein	-
KI818_RS07800 (1540076)	1540076..1540567	-	492	WP_000920038.1	staphylokinase	-
KI818_RS07805 (1540758)	1540758..1541513	-	756	WP_000861038.1	CHAP domain-containing protein	-
KI818_RS07810 (1541525)	1541525..1541779	-	255	WP_000611512.1	phage holin	-
KI818_RS07815 (1541831)	1541831..1541938	+	108	WP_031762631.1	hypothetical protein	-
- (1541860)	1541860..1541999	+	140	NuclAT_0	-	Antitoxin
- (1541860)	1541860..1541999	+	140	NuclAT_0	-	Antitoxin
- (1541860)	1541860..1541999	+	140	NuclAT_0	-	Antitoxin
- (1541860)	1541860..1541999	+	140	NuclAT_0	-	Antitoxin
KI818_RS07820 (1541991)	1541991..1542167	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KI818_RS07825 (1542370)	1542370..1543143	-	774	WP_044033830.1	staphylococcal enterotoxin type P	-
KI818_RS07830 (1543564)	1543564..1543938	-	375	WP_000340977.1	hypothetical protein	-
KI818_RS07835 (1543994)	1543994..1544281	-	288	WP_001040255.1	hypothetical protein	-
KI818_RS07840 (1544328)	1544328..1544480	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / see / hlb / groEL / hld	1486975..1608902	121927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T203876 WP_011447039.1 NZ_CP075562:c1542167-1541991 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T203876 NZ_CP100431:c2121883-2121626 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT203876 NZ_CP075562:1541860-1541999 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin