Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 691844..692571 Replicon chromosome
Accession NZ_CP075487
Organism Escherichia coli strain NT1F34

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag IGI26_RS04000 Protein ID WP_000550189.1
Coordinates 691844..692158 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IGI26_RS04005 Protein ID WP_000560266.1
Coordinates 692155..692571 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGI26_RS03980 (688011) 688011..688997 - 987 WP_001301393.1 Gfo/Idh/MocA family oxidoreductase -
IGI26_RS03985 (689076) 689076..689759 - 684 WP_001183040.1 vancomycin high temperature exclusion protein -
IGI26_RS03990 (689836) 689836..690339 - 504 WP_001295542.1 M48 family metallopeptidase -
IGI26_RS03995 (690424) 690424..691560 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
IGI26_RS04000 (691844) 691844..692158 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
IGI26_RS04005 (692155) 692155..692571 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
IGI26_RS04010 (692616) 692616..694634 - 2019 WP_193115115.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
IGI26_RS04015 (695060) 695060..697411 - 2352 WP_032181363.1 alpha-glucosidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T203801 WP_000550189.1 NZ_CP075487:691844-692158 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T203801 NZ_CP100338:c972209-971943 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT203801 WP_000560266.1 NZ_CP075487:692155-692571 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT203801 NZ_CP100338:c972444-972193 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML


Antitoxin

Source ID Structure

References