Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3602881..3603575 | Replicon | chromosome |
| Accession | NZ_CP075480 | ||
| Organism | Escherichia coli strain NT1N31 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | IGI30_RS17360 | Protein ID | WP_001263493.1 |
| Coordinates | 3602881..3603279 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | IGI30_RS17365 | Protein ID | WP_000554757.1 |
| Coordinates | 3603282..3603575 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3598541) | 3598541..3598621 | - | 81 | NuclAT_8 | - | - |
| - (3598541) | 3598541..3598621 | - | 81 | NuclAT_8 | - | - |
| - (3598541) | 3598541..3598621 | - | 81 | NuclAT_8 | - | - |
| - (3598541) | 3598541..3598621 | - | 81 | NuclAT_8 | - | - |
| IGI30_RS17330 (3597881) | 3597881..3599125 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| IGI30_RS17335 (3599217) | 3599217..3599675 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| IGI30_RS17340 (3599936) | 3599936..3601393 | + | 1458 | WP_001293016.1 | cytosol nonspecific dipeptidase | - |
| IGI30_RS17345 (3601450) | 3601450..3601971 | - | 522 | Protein_3412 | peptide chain release factor H | - |
| IGI30_RS17350 (3601970) | 3601970..3602173 | - | 204 | Protein_3413 | RtcB family protein | - |
| IGI30_RS17355 (3602419) | 3602419..3602871 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| IGI30_RS17360 (3602881) | 3602881..3603279 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| IGI30_RS17365 (3603282) | 3603282..3603575 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| IGI30_RS17370 (3603627) | 3603627..3604682 | - | 1056 | WP_193107709.1 | DNA polymerase IV | - |
| IGI30_RS17375 (3604753) | 3604753..3605538 | - | 786 | WP_000207587.1 | putative lateral flagellar export/assembly protein LafU | - |
| IGI30_RS17380 (3605510) | 3605510..3607222 | + | 1713 | Protein_3419 | flagellar biosynthesis protein FlhA | - |
| IGI30_RS17385 (3607446) | 3607446..3607943 | - | 498 | WP_193107710.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T203763 WP_001263493.1 NZ_CP075480:c3603279-3602881 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T203763 NZ_CP100314:16829-17311 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAAACAGTCCTCGA
TGAATGGCTAAAACACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCGAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTAAAACTTCCA
TGA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAAACAGTCCTCGA
TGAATGGCTAAAACACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCGAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTAAAACTTCCA
TGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT203763 WP_000554757.1 NZ_CP075480:c3603575-3603282 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT203763 NZ_CP100314:16575-16841 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCAGCTGCAGAGATCCTTCA
TAAATCGCGTACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCAGCTGCAGAGATCCTTCA
TAAATCGCGTACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|