Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3613497..3614191 Replicon chromosome
Accession NZ_CP075474
Organism Escherichia coli strain NT1N28

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag IGI29_RS18075 Protein ID WP_001263493.1
Coordinates 3613497..3613895 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag IGI29_RS18080 Protein ID WP_000554757.1
Coordinates 3613898..3614191 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3609157) 3609157..3609237 - 81 NuclAT_9 - -
- (3609157) 3609157..3609237 - 81 NuclAT_9 - -
- (3609157) 3609157..3609237 - 81 NuclAT_9 - -
- (3609157) 3609157..3609237 - 81 NuclAT_9 - -
IGI29_RS18045 (3608497) 3608497..3609741 - 1245 WP_000189541.1 esterase FrsA -
IGI29_RS18050 (3609833) 3609833..3610291 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
IGI29_RS18055 (3610552) 3610552..3612009 + 1458 WP_001293002.1 cytosol nonspecific dipeptidase -
IGI29_RS18060 (3612066) 3612066..3612587 - 522 Protein_3417 peptide chain release factor H -
IGI29_RS18065 (3612586) 3612586..3612789 - 204 Protein_3418 RtcB family protein -
IGI29_RS18070 (3613035) 3613035..3613487 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
IGI29_RS18075 (3613497) 3613497..3613895 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
IGI29_RS18080 (3613898) 3613898..3614191 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
IGI29_RS18085 (3614243) 3614243..3615298 - 1056 WP_001226164.1 DNA polymerase IV -
IGI29_RS18090 (3615369) 3615369..3616154 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
IGI29_RS18095 (3616126) 3616126..3617838 + 1713 Protein_3424 flagellar biosynthesis protein FlhA -
IGI29_RS18100 (3618054) 3618054..3618550 - 497 Protein_3425 REP-associated tyrosine transposase RayT -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-130)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T203711 WP_001263493.1 NZ_CP075474:c3613895-3613497 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T203711 NZ_CP100290:5621-6154 [Burkholderia glumae]
ATGATCCTCACGCCGTTGCAGGACATCACGGCCTATCGCATGCATGTGCCCAAGTGGGCCGTCGCGCCCACCAGCGGCGC
GGGCGCGGCCAAGGCCGGGGGGCGGGCCAACCGGATCGGCACGCCGGCGTTGTACCTGGCGCTGGAGGCGTCCACCGCGG
TGGCCGAGTACCAGCAGCTGTCGCCCCTGTTGCCGCCGGGCACGTTGGTGAGCTATCGCGTCACGGCCACGCCCGTGGTC
GATTTCACCGGCGGCTACCGTGCGGATCTCTGGCCGCCCCTCTGGGAGTCGTTCTTCTGCGACTGGCGGCATGACTGGTT
CAACGCGCGCATTGAGCCGCCCAGCTGGGTACTCGGCGACGAGGCAATCGCCTCCGGCGCCAAGGGCATCCTGTTTCGCT
CGACGCAGGCCGCCGGCGGCACGAACTTGGTGCTGTTCGTCGACCAGTTGGGGGAGGGCGATCGCGTGGATGTTCACGAC
CCGGCCGGCGCCTTGCCGCGCGATCAAGCGTCGTGGGCTGACTCGCCCGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT203711 WP_000554757.1 NZ_CP075474:c3614191-3613898 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT203711 NZ_CP100290:5208-5624 [Burkholderia glumae]
ATGAGCACTCTCGCAGCAGCGCGAGCACCCGCCGGCGGTCCGGCCCTGGCAAACTTTGACGCGTTTCTCAGCGCGCTACG
CGAGCCGGACACGGCCGCTCCCGTGCTGTCGGCTCGTCGCTACGTGGCGGCCCTCAACATCGACCTGCAGACGCTCGCGG
ACCAGGCTCACGTCCATCGCAACACCGTCGCGCGCGCGCCGCAGTCAGCCAGCGTCCAGCAGTTTCTGCGCGAGGCGATT
CGCGTGATCCGAGCCGCGACGGATCTGTCGGGCGACGTTCAACGCGCGCTGTTCTGGTATCGCAACGAGCCTCTGGCCGT
CTTCGATTACCAGACGGCCGAAACGCTGGTGTCGGCAGGGCGCGCCGATGACGTTGTGCGCTATGTGGCATCGCTCGAGG
CGGGCGCCGCCGGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1EXB8


Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References