Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 736020..736713 Replicon chromosome
Accession NZ_CP075469
Organism Escherichia coli strain NT1W22

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IGI32_RS03585 Protein ID WP_000415584.1
Coordinates 736020..736316 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IGI32_RS03590 Protein ID WP_000650107.1
Coordinates 736318..736713 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGI32_RS03550 (731108) 731108..731422 - 315 WP_000958598.1 putative quinol monooxygenase -
IGI32_RS03555 (731453) 731453..732034 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IGI32_RS03560 (732353) 732353..732685 + 333 WP_000917684.1 DUF2645 family protein -
IGI32_RS03565 (732731) 732731..734080 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
IGI32_RS03570 (734077) 734077..734736 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
IGI32_RS03575 (734888) 734888..735280 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IGI32_RS03580 (735333) 735333..735815 + 483 WP_000183505.1 GyrI-like domain-containing protein -
IGI32_RS03585 (736020) 736020..736316 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IGI32_RS03590 (736318) 736318..736713 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IGI32_RS03595 (736846) 736846..738453 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IGI32_RS03600 (738591) 738591..740849 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T203647 WP_000415584.1 NZ_CP075469:736020-736316 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T203647 NZ_CP100217:c125215-124865 [Burkholderia glumae]
ATGGTGAAGCGGGTCAAGTTCGAGCGAGGCGATATCGTGCGAGTGAGTCTGAGTCCGACGGTCGGCCGTGAGCAGCAAGG
AGATTTTCGTCCCGCGCTTGTGCTCTCTCCGGCGGCGTTTAACGCGCTGGGTGTGGCGCTCGTTGCCCCGATTACCCAGG
GCGGTGAATTCGCCCGCTTTGCAGGTTTTGCGGTTCCGCTCTCCGGTTCGGGGACGGAGACACAGGGAGTGGCACTGGTG
AACATGGTACGCATGCTCGACTTGGAAGGACGCGGCGCACGCAAGATCGAACGCGCGCCCGTCGAAGTGGTAGAGGATGC
CCTGGCCCGTCTTCAAACGATTATTGAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT203647 WP_000650107.1 NZ_CP075469:736318-736713 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT203647 NZ_CP100217:c125460-125209 [Burkholderia glumae]
ATGGAACTAAAGATTCAGAAATGGGGCAATAGCGCGGCGGTGCGTTTGCCGAGCGTATTGCTCGAACAGATCAACGCATC
GGTCGGCGGTTCGCTGAACGCGGACGTGCGGCCGGATGGGGTGCTACTGACCCCGGCCCGGCGGAAGTATGCGCTGGATG
ATCTCGTGGCTCAGTGCGACACGAAGGCGCCTGTTCCGGCCGACATGGCAGCCTGGGGCGAGATCAAGCCGGTGGGACGT
GAAGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References