Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4834681..4835283 Replicon chromosome
Accession NZ_CP075372
Organism Salmonella enterica strain no75

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag KH432_RS23795 Protein ID WP_001159630.1
Coordinates 4834972..4835283 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KH432_RS23790 Protein ID WP_000362050.1
Coordinates 4834681..4834971 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH432_RS23775 (4832174) 4832174..4833076 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
KH432_RS23780 (4833073) 4833073..4833708 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
KH432_RS23785 (4833705) 4833705..4834634 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
KH432_RS23790 (4834681) 4834681..4834971 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
KH432_RS23795 (4834972) 4834972..4835283 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
KH432_RS23800 (4835501) 4835501..4836430 + 930 WP_001127703.1 alpha/beta hydrolase -
KH432_RS23805 (4836516) 4836516..4836827 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
KH432_RS23810 (4836824) 4836824..4837270 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
KH432_RS23815 (4837285) 4837285..4838226 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
KH432_RS23820 (4838271) 4838271..4838708 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
KH432_RS23825 (4838705) 4838705..4839577 - 873 WP_000921427.1 virulence factor BrkB family protein -
KH432_RS23830 (4839571) 4839571..4840170 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T203531 WP_001159630.1 NZ_CP075372:c4835283-4834972 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T203531 NZ_CP100112:7180-7596 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT203531 WP_000362050.1 NZ_CP075372:c4834971-4834681 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT203531 NZ_CP100112:6953-7183 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64


Antitoxin

Source ID Structure

References