Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 736624..737399 Replicon chromosome
Accession NZ_CP075286
Organism Klebsiella pneumoniae strain YTF44-1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag KI725_RS03745 Protein ID WP_004150910.1
Coordinates 736914..737399 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag KI725_RS03740 Protein ID WP_004150912.1
Coordinates 736624..736917 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI725_RS03720 (KI725_03720) 731832..732434 - 603 WP_002916735.1 short chain dehydrogenase -
KI725_RS03725 (KI725_03725) 732532..733443 + 912 WP_004188550.1 LysR family transcriptional regulator -
KI725_RS03730 (KI725_03730) 733444..734592 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
KI725_RS03735 (KI725_03735) 734603..735979 - 1377 WP_004217775.1 cystathionine beta-synthase -
KI725_RS03740 (KI725_03740) 736624..736917 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
KI725_RS03745 (KI725_03745) 736914..737399 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
KI725_RS03750 (KI725_03750) 738103..738696 + 594 WP_004188553.1 hypothetical protein -
KI725_RS03755 (KI725_03755) 738793..739009 + 217 Protein_725 transposase -
KI725_RS03760 (KI725_03760) 739615..740487 + 873 WP_004188557.1 ParA family protein -
KI725_RS03765 (KI725_03765) 740487..740870 + 384 WP_004150906.1 hypothetical protein -
KI725_RS03770 (KI725_03770) 740863..742230 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 738793..738945 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T203407 WP_004150910.1 NZ_CP075286:736914-737399 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T203407 NZ_CP100076:1922762-1922864 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT203407 WP_004150912.1 NZ_CP075286:736624-736917 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT203407 NZ_CP100076:c1922871-1922726 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References