Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5090593..5091239 Replicon chromosome
Accession NZ_CP075256
Organism Klebsiella pneumoniae strain SZP4-9-2

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag KI741_RS24955 Protein ID WP_032433636.1
Coordinates 5090892..5091239 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag KI741_RS24950 Protein ID WP_019725405.1
Coordinates 5090593..5090892 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI741_RS24930 (5086799) 5086799..5087557 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
KI741_RS24935 (5087607) 5087607..5088437 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
KI741_RS24940 (5088488) 5088488..5088817 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
KI741_RS24945 (5089022) 5089022..5090530 + 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
KI741_RS24950 (5090593) 5090593..5090892 - 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
KI741_RS24955 (5090892) 5090892..5091239 - 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI741_RS24960 (5091415) 5091415..5093862 - 2448 WP_032433638.1 glycogen phosphorylase -
KI741_RS24965 (5093880) 5093880..5095313 - 1434 WP_032433640.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T203400 WP_032433636.1 NZ_CP075256:c5091239-5090892 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T203400 NZ_CP100073:c6153-5848 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT203400 WP_019725405.1 NZ_CP075256:c5090892-5090593 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT203400 NZ_CP100073:c6373-6155 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References