Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-agrB/Ldr(toxin)
Location 4509353..4509574 Replicon chromosome
Accession NC_002655
Organism Escherichia coli O157:H7 str. EDL933

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag Z_RS31045 Protein ID WP_001295224.1
Coordinates 4509353..4509460 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4509509..4509574 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Z_RS23255 (Z4949) 4504606..4505358 - 753 Protein_4426 cellulose biosynthesis protein BcsQ -
Z_RS23265 (Z4951) 4505370..4505558 - 189 WP_001063316.1 YhjR family protein -
Z_RS23270 (Z4952) 4505831..4507402 + 1572 WP_001204920.1 cellulose biosynthesis protein BcsE -
Z_RS23275 (Z4953) 4507399..4507590 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
Z_RS23280 (Z4954) 4507587..4509266 + 1680 WP_000191598.1 cellulose biosynthesis protein BcsG -
Z_RS31045 4509353..4509460 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 4509509..4509574 + 66 - - Antitoxin
Z_RS23295 (Z4956) 4509936..4511207 + 1272 WP_010904940.1 amino acid permease -
Z_RS23300 (Z4957) 4511237..4512241 - 1005 WP_000107027.1 dipeptide ABC transporter ATP-binding subunit DppF -
Z_RS23305 (Z4958) 4512238..4513221 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
Z_RS23310 (Z4959) 4513232..4514134 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T20338 WP_001295224.1 NC_002655:c4509460-4509353 [Escherichia coli O157:H7 str. EDL933]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T20338 NC_002655:c4509460-4509353 [Escherichia coli O157:H7 str. EDL933]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 66 bp

>AT20338 NC_002655:4509509-4509574 [Escherichia coli O157:H7 str. EDL933]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References